首页 Metabolism NADPH Dicumarol
Dicumarol
编号 T0809     别名: Dicoumarol
CAS 66-76-2     分子式 C19H12O6     分子量 336.29
靶点: NQO1; PDK1;
Dicumarol is a hydroxycoumarin originally isolated from molding sweet-clover hay, with anticoagulant and vitamin K depletion activities. Dicumarol is a competitive inhibitor of vitamin K epoxidereductase; thus, it inhibits vitamin K recycling and causes depletion of active vitamin K in blood. This prevents the formation of the active form of prothrombin and several other coagulant enzymes, and inhibits blood clotting.
选择批次  
规格 库存 单价 数量
25 mg 上海现货 262.00
50 mg 上海现货 321.00
100 mg 上海现货 417.00
200 mg 上海现货 584.00
1 mL * 10 mM (in DMSO) 上海现货 385.00
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生物活性

产品描述

Dicumarol is a hydroxycoumarin originally isolated from molding sweet-clover hay, with anticoagulant and vitamin K depletion activities. Dicumarol is a competitive inhibitor of vitamin K epoxidereductase; thus, it inhibits vitamin K recycling and causes depletion of active vitamin K in blood. This prevents the formation of the active form of prothrombin and several other coagulant enzymes, and inhibits blood clotting.

靶点活性

NQO1,0.37μM

PDK1,19.42μM

体外活性

体内活性

化学信息

分子量

336.29

分子式

C19H12O6

CAS

66-76-2

溶解度

DMSO: 62 mg/mL (184.4 mM)

Ethanol: 62 mg/mL (184.4 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 2.974 ml 14.868 ml 29.736 ml
5 mM 0.595 ml 2.974 ml 5.947 ml
10 mM 0.297 ml 1.487 ml 2.974 ml
50 mM 0.059 ml 0.297 ml 0.595 ml
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