Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Detomidine carboxylic acid is the main urine metabolite of detomidine. Detomidine is a synthetic α2-adrenergic agonist and an animal analgesic. Detomidine also has heart and breathing effects, and has a diuretic effect.
产品描述 | Detomidine carboxylic acid is the main urine metabolite of detomidine. Detomidine is a synthetic α2-adrenergic agonist and an animal analgesic. Detomidine also has heart and breathing effects, and has a diuretic effect. |
体内活性 | After oral administration of Detomidine, an analgesic sedative for large animals, to two stallions and intravenous injection of [3H]-Detomidine into mares, the metabolites in horse urine were studied. After oral doses, a combination of totomidine carboxylic acid and hydroxytomtomidine glucuronic acid was identified in the urine. About 12 hours after the intravenous injection, about half of the radioactivity of [3H]-tomtomidine was excreted into the urine. Dose (80μg/kg). Compared with the highest urine output 2 to 5 hours after urination, most excretion occurs between 5 and 12 hours. The main radioactive metabolite in urine is totomidine carboxylic acid. In all collected urine fractions, totomidine carboxylic acid accounts for more than two-thirds of the total metabolites. |
分子量 | 216.24 |
分子式 | C12H12N2O2 |
CAS No. | 115664-39-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Detomidine carboxylic acid 115664-39-6 GPCR/G Protein Neuroscience Adrenergic Receptor Inhibitor inhibitor inhibit