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Detomidine carboxylic acid

Detomidine carboxylic acid

产品编号 T11010   CAS 115664-39-6

Detomidine carboxylic acid is the main urine metabolite of detomidine. Detomidine is a synthetic α2-adrenergic agonist and an animal analgesic. Detomidine also has heart and breathing effects, and has a diuretic effect.

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Detomidine carboxylic acid Chemical Structure
Detomidine carboxylic acid, CAS 115664-39-6
规格 价格/CNY 货期 数量
100 mg 待询 待询
500 mg 待询 待询
千万补贴 助力科研
BCA蛋白浓度测定试剂盒限时半价
重组蛋白限时优惠
产品目录号及名称: Detomidine carboxylic acid (T11010)
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参考文献
产品描述 Detomidine carboxylic acid is the main urine metabolite of detomidine. Detomidine is a synthetic α2-adrenergic agonist and an animal analgesic. Detomidine also has heart and breathing effects, and has a diuretic effect.
体内活性 After oral administration of Detomidine, an analgesic sedative for large animals, to two stallions and intravenous injection of [3H]-Detomidine into mares, the metabolites in horse urine were studied. After oral doses, a combination of totomidine carboxylic acid and hydroxytomtomidine glucuronic acid was identified in the urine. About 12 hours after the intravenous injection, about half of the radioactivity of [3H]-tomtomidine was excreted into the urine. Dose (80μg/kg). Compared with the highest urine output 2 to 5 hours after urination, most excretion occurs between 5 and 12 hours. The main radioactive metabolite in urine is totomidine carboxylic acid. In all collected urine fractions, totomidine carboxylic acid accounts for more than two-thirds of the total metabolites.
分子量 216.24
分子式 C12H12N2O2
CAS No. 115664-39-6

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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TargetMol Library Books参考文献

1. Salonen JS, et al. Identification of detomidine carboxylic acid as the major urinary metabolite of detomidine in the horse. Eur J Drug Metab Pharmacokinet. 1992 Jan-Mar;17(1):13-20. 2. Virtanen R, et al. Pharmacological evidence for the involvement of alpha-2 adrenoceptors in the sedative effect of detomidine, a novel sedative-analgesic. J Vet Pharmacol Ther. 1985 Mar;8(1):30-7.
Tamsulosin hydrochloride Carbazochrome sodium sulfonate nifenalol.HCl Dapiprazole Hydrochloride ACTH 1-14 acetate(25696-21-3 free base) JP1302 dihydrochloride (±)-Levomepromazine-d6 L-771688

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Keywords

Detomidine carboxylic acid 115664-39-6 GPCR/G Protein Neuroscience Adrenergic Receptor Inhibitor inhibitor inhibit

 

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