Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Denifanstat (FASN-IN-2) 是一种口服具有活性的选择性 FASN 抑制剂,IC50=0.052 μM,EC50=0.072 μM。它有用于脂肪肝和癌症的研究潜力。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 696 | 现货 | ||
5 mg | ¥ 1,680 | 现货 | ||
10 mg | ¥ 2,530 | 现货 | ||
25 mg | ¥ 4,260 | 现货 | ||
50 mg | ¥ 5,930 | 现货 | ||
100 mg | ¥ 8,370 | 现货 | ||
500 mg | ¥ 16,700 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,850 | 现货 |
产品描述 | Denifanstat (FASN-IN-2) is a Fatty Acid Synthase (FASN) inhibitor(IC50 of 0.052 μM and an EC50 of 0.072 μM),with potential antineoplastic activity. |
靶点活性 | FASN:0.052 μM |
体外活性 |
TVB-2640 is an orally bioavailable fatty acid synthase (FASN) inhibitor, with potential antineoplastic activity. Upon administration, TVB-2640 binds to and blocks FASN, which prevents the synthesis of palmitate needed for tumor cell growth and survival. This leads to a reduction in cell signaling, an induction of tumor cell apoptosis and the inhibition of cell proliferation in susceptible tumor cells. FASN, an enzyme responsible for the de novo synthesis of palmitic acid, is overexpressed in tumor cells and plays a key role in tumor metabolism, lipid signaling, tumor cell survival and drug resistance; tumor cells are dependent on increased fatty acid production for their enhanced metabolic needs and rapid growth. Check for active clinical trials or closed clinical trials using this agent. |
别名 | FASN-IN-2, TVB2640, TVB-2640 |
分子量 | 439.55 |
分子式 | C27H29N5O |
CAS No. | 1399177-37-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (568.76 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.2751 mL | 11.3753 mL | 22.7505 mL | 56.8764 mL |
5 mM | 0.455 mL | 2.2751 mL | 4.5501 mL | 11.3753 mL | |
10 mM | 0.2275 mL | 1.1375 mL | 2.2751 mL | 5.6876 mL | |
20 mM | 0.1138 mL | 0.5688 mL | 1.1375 mL | 2.8438 mL | |
50 mM | 0.0455 mL | 0.2275 mL | 0.455 mL | 1.1375 mL | |
100 mM | 0.0228 mL | 0.1138 mL | 0.2275 mL | 0.5688 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Denifanstat 1399177-37-7 Metabolism Fatty Acid Synthase SARS-CoV2 FASN-IN-2 ASC40 Inhibitor spike TVB2640 inhibit ASC 40 TVB-2640 TVB 2640 Fatty Acid Synthase (FASN) protein COVID-19 ASC-40 inhibitor