首页 Cytoskeletal Signaling Akt Dehydroglyasperin C
Dehydroglyasperin C
编号 TN3806    
CAS 199331-35-6     分子式 C21H22O5     分子量 354.4
靶点: Akt; AP-1; COX; ERK; HO-1; IkB; IKK; JNK; NADPH; NF-κB; Nrf2; p38 MAPK; p65; PI3K; TNF-α;
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemopreventive, and neuroprotective activities, it has protective effects against chronic diseases caused by reactive oxygen species as well as potential as an antioxidant food additive. Dehydroglyasperin C protects neuronal cells against glutamate-induced oxidative injury through the induction of HO-1 expression, which is, in turn, activated maybe through Nrf2-Keap1 and PI3K/AKT signaling pathways.
选择批次  
纯度 98.00%
规格 库存 单价 数量
1 mg 待询 待询
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生物活性

产品描述

Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemopreventive, and neuroprotective activities, it has protective effects against chronic diseases caused by reactive oxygen species as well as potential as an antioxidant food additive. Dehydroglyasperin C protects neuronal cells against glutamate-induced oxidative injury through the induction of HO-1 expression, which is, in turn, activated maybe through Nrf2-Keap1 and PI3K/AKT signaling pathways.

靶点活性

Akt,

AP-1,

COX,

ERK,

HO-1,

IkB,

IKK,

JNK,

NADPH,

NF-κB,

Nrf2,

p38 MAPK,

p65,

PI3K,

TNF-α,

体外活性

体内活性

化学信息

分子量

354.4

分子式

C21H22O5

CAS

199331-35-6

溶解度

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 2.822 ml 14.108 ml 28.217 ml
5 mM 0.564 ml 2.822 ml 5.643 ml
10 mM 0.282 ml 1.411 ml 2.822 ml
50 mM 0.056 ml 0.282 ml 0.564 ml
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