Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dehydroevodiamine hydrochloride 是分离自吴茱萸叶中,能够抑制 AChE。 它能够调节一氧化氮的产生,具有降压和神经保护作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 184 | 现货 | ||
5 mg | ¥ 414 | 现货 | ||
10 mg | ¥ 663 | 现货 | ||
25 mg | ¥ 970 | 现货 | ||
50 mg | ¥ 1,370 | 待询 | ||
100 mg | ¥ 1,980 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 498 | 现货 |
产品描述 | Dehydroevodiamine (DHE), a natural compound isolated from Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production. |
体内活性 | Dehydroevodiaminehydrochloride has strong protective effects against cognitive impairments through its antioxidant activity and inhibition of neurotoxicity and intracellular calcium. Thus, DHED may be an important therapeutic agent for memory-impaired symptoms. |
动物实验 | The effects of dehydroevodiamine·HCl (DHED) on cognitive improvement and the related mechanism in memory-impaired rat models, namely, a scopolamine-induced amnesia model and a Aβ1-42-infused model. The cognitive effects of DHED were measured using a water maze test and a passive avoidance test in the memory-impaired rat models. The results demonstrate that DHED (10 mg/kg, p.o.) and Donepezil (1 mg/kg, p.o.) ameliorated the spatial memory impairment in the scopolamine-induced amnestic rats. |
分子量 | 337.8 |
分子式 | C19H16ClN3O |
CAS No. | 111664-82-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 37 mg/mL (109.53 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.9603 mL | 14.8017 mL | 29.6033 mL | 74.0083 mL |
5 mM | 0.5921 mL | 2.9603 mL | 5.9207 mL | 14.8017 mL | |
10 mM | 0.296 mL | 1.4802 mL | 2.9603 mL | 7.4008 mL | |
20 mM | 0.148 mL | 0.7401 mL | 1.4802 mL | 3.7004 mL | |
50 mM | 0.0592 mL | 0.296 mL | 0.5921 mL | 1.4802 mL | |
100 mM | 0.0296 mL | 0.148 mL | 0.296 mL | 0.7401 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Dehydroevodiamine hydrochloride 111664-82-5 Neuroscience AChE inhibit Inhibitor Dehydroevodiamine Hydrochloride Dehydroevodiamine inhibitor