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Deferoxamine Mesylate

产品编号 T1637 CAS 138-14-7

别名: desferrioxamine B, Desferrioxamine B mesylate, DFO, DFOM, 去铁铵, 甲磺酸去铁胺

Deferoxamine Mesylate (DFOM) 是一种铁螯合剂和铁死亡抑制剂。Deferoxamine Mesylate 可将游离铁结合成稳定的复合物，减少铁的积累。Deferoxamine Mesylate 可以上调 HIF-1α 水平，诱导细胞凋亡。

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Deferoxamine Mesylate Chemical Structure

Deferoxamine Mesylate, CAS 138-14-7

规格	价格/CNY	货期
25 mg	￥ 193	现货
100 mg	￥ 373	现货
500 mg	￥ 935	现货
1 mL * 10 mM (in DMSO)	￥ 383	现货

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其他形式的 Deferoxamine Mesylate:

Deferoxamine
现货
1,8-Diazafluoren-9-one
现货

选择批次

纯度: 99.8%

纯度: 99.65%

纯度: 99.45%

纯度: 99.18%

纯度: 99.13%

纯度: 99.04%

纯度: 98.52%

纯度: 98.34%

纯度: 98%

纯度: 94.68%

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生物活性

化学信息

存储 & 溶解度

参考文献

相关产品

拓展阅读

产品描述	Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor. Deferoxamine Mesylate binds free iron into a stable complex and reduces iron accumulation. Deferoxamine Mesylate up-regulates HIF-1α levels and induces apoptosis.
体外活性	方法：人宫颈癌细胞 HeLa 用 Deferoxamine Mesylate (3-100 μM) 处理 72 h，使用 Incucyte HD imaging system 检测细胞数目。结果：Deferoxamine Mesylate 以浓度依赖的方式抑制细胞生长，在100 μM 下观察到显著的生长抑制。[1] 方法：人结直肠癌细胞 HT29 和 HCT116 用 Deferoxamine Mesylate (50-200 μM) 处理 48 h，使用 Western Blot 方法检测靶点蛋白表达水平。结果：Deferoxamine Mesylate 以剂量依赖性方式诱导 HIF-1α 的显著表达。[2] 方法：人乳腺癌细胞 MDA-MB-231 和 MCF-7 用 Deferoxamine Mesylate (200 μM) 处理 24 h，使用 Flow Cytometry 方法检测细胞凋亡情况。结果：Deferoxamine Mesylate 处理后，与未处理的细胞相比，MDA-MB-231 细胞的凋亡率没有变化，而 MCF-7 细胞的凋亡显著增加。[3]
体内活性	方法：为研究 Deferoxamine Mesylate 是否能减轻实验小鼠的炎症和动脉粥样硬化，将 Deferoxamine Mesylate (100 mg/kg) 腹腔注射给载脂蛋白 E 缺陷 (apoE-/-) 小鼠，每天一次，持续十周。结果：Deferoxamine Mesylate 使主动脉动脉粥样硬化病变的发展减少 26%。Deferoxamine Mesylate 还降低了血清 MCP-1 水平以及主动脉和心脏中促炎和巨噬细胞标志物的基因表达，同时增加了心脏和肝脏中转铁蛋白受体的蛋白质表达。相反，Deferoxamine Mesylate 治疗对血清胆固醇和甘油三酯水平没有影响。[4] 方法：为研究 Deferoxamine Mesylate 对 ob/ob 小鼠附睾脂肪组织中脂肪细胞功能障碍的影响，将 Deferoxamine Mesylate (100 mg/kg) 腹腔注射给 ob/ob 小鼠，每天一次，持续十五天。结果：Deferoxamine Mesylate 通过减少活性氧和炎症标志物的分泌，通过增加抗氧化酶、HIF-1α 和 HIF-1α 靶向蛋白的水平，以及通过改变脂肪细胞铁、葡萄糖和脂质相关代谢蛋白，显著改善了脂肪组织生物学的重要参数。同时，Deferoxamine Mesylate 治疗后，肥大的脂肪细胞体积缩小，胰岛素信号通路相关蛋白也被激活。[5]
细胞实验	After cells were seeded onto the collagen-GAG discs and allowed to adhere for 3?hours, they were placed into a hypoxic incubator with 1% O2 or incubated under standard cell culture conditions with deferoxamine mesylate (DFO) added to final concentrations of 30, 60, or 120?μM. Scaffolds seeded with AdMSCs cultured under standard conditions were used as a control [3].
动物实验	The animals were divided into 4 groups: sham, SAH, SAH+vehicle and SAH+DFX (100mg/kg) group. DFX was administered intraperitoneally 2 and 6 hours after hemorrhage followed by every 12 hours for a maximum of 7 days. The same time course and dosage of saline were administered in the SAH+vehicle group. Afterward, rats underwent behavioral testing and were euthanized at day 1, 3, 7 and 28 for brain water content calculation, immunohistochemistry or western blot assays. The study was performed in three parts. Part 1 measured the brain water content, Evan's blue extravasation, and ultrastructural abnormalities at day 1, 3 and 7 after SAH to evaluate the time-dependent changes in brain edema and BBB disruption (n = 4 per time point and group). Part 2 investigated the role of iron in SAH-induced BBB disruption at day 1, 3 and 7 by brain water content (n = 4, per time point and group), Evan's blue extravasation (n = 4, per time point and group), transmission electron microscopy (n = 4, per time point and group), immunohistochemistry (n = 4, per time point and group) and western blot analysis (n = 3, per time point and group). Part 3 compared the acute (n = 61, per group at day 1; n = 42, per group at day 3; n = 23, per group at day 7) and long term (n = 4, per group at day 28) neurological function after SAH in each group to determine the effect of iron chelation on SAH-induced neurologic impairment [4].

别名	desferrioxamine B, Desferrioxamine B mesylate, DFO, DFOM, 去铁铵, 甲磺酸去铁胺
化合物与蛋白结合的复合物	Crystal structure of ferric R-state human methemoglobin bound to maleimide-deferoxamine bifunctional chelator (DFO)
分子量	656.79
分子式	C26H52N6O11S
CAS No.	138-14-7

存储

store at low temperature,keep away from direct sunlight　|　Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 152.3 mM

H2O: 20.83 mg/mL (31.72 mM)

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
DMSO / H2O	1 mM	1.5226 mL	7.6128 mL	15.2256 mL	38.0639 mL
	5 mM	0.3045 mL	1.5226 mL	3.0451 mL	7.6128 mL
	10 mM	0.1523 mL	0.7613 mL	1.5226 mL	3.8064 mL
	20 mM	0.0761 mL	0.3806 mL	0.7613 mL	1.9032 mL
DMSO	50 mM	0.0305 mL	0.1523 mL	0.3045 mL	0.7613 mL
DMSO	100 mM	0.0152 mL	0.0761 mL	0.1523 mL	0.3806 mL

计算器

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参考文献

1. Fujisawa K, et al. An iron chelation-based combinatorial anticancer therapy comprising deferoxamine and a lactate excretion inhibitor inhibits the proliferation of cancer cells. Cancer Metab. 2022 May 12;10(1):8. 2. Zhang W, et al. Deferoxamine enhances cell migration and invasion through promotion of HIF-1α expression and epithelial-mesenchymal transition in colorectal cancer. Oncol Rep. 2014 Jan;31(1):111-6. 3. Chen C, et al. Deferoxamine Enhanced Mitochondrial Iron Accumulation and Promoted Cell Migration in Triple-Negative MDA-MB-231 Breast Cancer Cells Via a ROS-Dependent Mechanism. Int J Mol Sci. 2019 Oct 8;20(19):4952. 4. Zhang WJ, et al. The iron chelator, desferrioxamine, reduces inflammation and atherosclerotic lesion development in experimental mice. Exp Biol Med (Maywood). 2010 May;235(5):633-41. 5. Yan HF, et al. Deferoxamine ameliorates adipocyte dysfunction by modulating iron metabolism in ob/ob mice. Endocr Connect. 2018 Apr;7(4):604-616. 6. Duscher D, et al. Comparison of the Hydroxylase Inhibitor Dimethyloxalylglycine and the Iron Chelator Deferoxamine in Diabetic and Aged Wound Healing. Plast Reconstr Surg. 2017 Mar;139(3):695e-706e 8. Sang M, Luo R, Bai Y, et al. BHQ-Cyanine-Based “Off–On” Long-Circulating Assembly as a Ferroptosis Amplifier for Cancer Treatment: A Lipid-Peroxidation Burst Device[J]. ACS applied materials & interfaces. 2019, 11(46): 42873-42884. 9. Sang M, Luo R, Bai Y, et al. BHQ-Cyanine Based “Off-On” Long-Circulating Assembly as Ferroptosis Amplifier for Cancer Treatment: a Lipid-Peroxidation Burst Device[J]. ACS applied materials & interfaces. 2019. 10. Wang S, Li F, Qiao R, et al. Arginine-Rich Manganese Silicate Nanobubbles as a Ferroptosis-Inducing Agent for Tumor-Targeted Theranostics[J]. ACS nano. 2018 Dec 26;12(12):12380-12392.

文献引用

1. Bi G, Liang J, Shan G, et al.Retinol saturase mediates retinoid metabolism to impair a ferroptosis defense system in cancer cells.Cancer Research.2023: CAN-22-3977. 2. Zhu X, Huang N, Ji Y, et al.Brusatol induces ferroptosis in oesophageal squamous cell carcinoma by repressing GSH synthesis and increasing the labile iron pool via inhibition of the NRF2 pathway.Biomedicine & Pharmacotherapy.2023, 167: 115567. 3. Chen T, Leng J, Tan J, et al.Discovery of Novel Potent Covalent Glutathione Peroxidase 4 Inhibitors as Highly Selective Ferroptosis Inducers for the Treatment of Triple-Negative Breast Cancer.Journal of Medicinal Chemistry.2023 4. Zhao G, Liang J, Shan G, et al.KLF11 regulates lung adenocarcinoma ferroptosis and chemosensitivity by suppressing GPX4.Communications Biology.2023, 6(1): 570. 5. Liu J, Pan Z, Tong B, et al.Artesunate protects against ocular fibrosis by suppressing fibroblast activation and inducing mitochondria‐dependent ferroptosis.The FASEB Journal.2023, 37(6): e22954. 6. Li Y, Bao Y, Li Y, et al.RSL3 Inhibits Porcine Epidemic Diarrhea Virus Replication by Activating Ferroptosis.Viruses.2023, 15(10): 2080. 7. Gao X, Jiang P, Wei X, et al.Novel fusion protein PK5-RL-Gal-3C inhibits hepatocellular carcinoma via anti-angiogenesis and cytotoxicity.BMC cancer.2023, 23(1): 1-16. 8. Besskaya V, Zhang H, Bian Y, et al.Hepatic nuclear factor 4 alpha promotes the ferroptosis of lung adenocarcinoma via transcriptional activation of cytochrome P450 oxidoreductase.PeerJ.2023, 11: e15377. 9. Zhou Y, Wu H, Wang F, et al. GPX7 Is Targeted by miR-29b and GPX7 Knockdown Enhances Ferroptosis Induced by Erastin in Glioma. Frontiers in oncology. 2021, 11: 802124-802124. 10. Bi G, Liang J, Zhao M, et al. MiR-6077 promotes cisplatin/pemetrexed resistance in lung adenocarcinoma by targeting CDKN1A/cell cycle arrest and KEAP1/ferroptosis pathways. Molecular Therapy-Nucleic Acids. 2022

11. Huang C Y, Chen L J, Chen G, et al. SHP-1/STAT3-Signaling-Axis-Regulated Coupling between BECN1 and SLC7A11 Contributes to Sorafenib-Induced Ferroptosis in Hepatocellular Carcinoma. International Journal of Molecular Sciences. 2022, 23(19): 11092. 12. Sang M, Luo R, Bai Y, et al. BHQ-Cyanine-Based “Off–On” Long-Circulating Assembly as a Ferroptosis Amplifier for Cancer Treatment: A Lipid-Peroxidation Burst Device. ACS applied materials & interfaces. 2019, 11(46): 42873-42884. 13. Wang S, Li F, Qiao R, et al. Arginine-Rich Manganese Silicate Nanobubbles as a Ferroptosis-Inducing Agent for Tumor-Targeted Theranostics. ACS nano. 2018 Dec 26;12(12):12380-12392. 14. Fang Y, Tan Q, Zhou H, et al. Discovery and optimization of 2-(trifluoromethyl) benzimidazole derivatives as novel ferroptosis inducers in vitro and in vivo. European Journal of Medicinal Chemistry. 2022: 114905. 15. Lv Q, Niu H, Yue L, et al. Abnormal Ferroptosis in Myelodysplastic Syndrome. Frontiers in Oncology. 2020 Sep 2;10:1656 16. Deng F, Xu G, Cheng Z, et al. Hepatitis B Surface Antigen Suppresses the Activation of Nuclear Factor Kappa B Pathway via Interaction With the TAK1-TAB2 Complex. Frontiers in Immunology. 2021, 12: 233. 17. Liu Y, Li H, Luo Z, et al. Artesunate, a new antimalarial clinical drug, exhibits potent anti‐AML activity by targeting the ROS/Bim and TFRC/Fe2+ pathways. British Journal of Pharmacology. 2022 18. Sang M, Luo R, Bai Y, et al. Mitochondrial membrane anchored photosensitive nano-device for lipid hydroperoxides burst and inducing ferroptosis to surmount therapy-resistant cancer. Theranostics. 2019, 9(21): 6209. 19. Wu W Y, Wang Z X, Li T S, et al. SSBP1 drives high fructose-induced glomerular podocyte ferroptosis via activating DNA-PK/p53 pathway. Redox Biology. 2022: 102303. 20. Ouyang S, Li H, Lou L, et al. Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer. Redox Biology. 2022: 102317 21. Li X, Wang H, Lu Z, et al. Development of Multifunctional Pyrimidinylthiourea Derivatives as Potential Anti-Alzheimer Agents. Journal of Medicinal Chemistry. 2016 Sep 22;59(18):8326-44 22. Cheng Y, Qu W, Li J, et al. Ferristatin II, an Iron Uptake Inhibitor, Exerts Neuroprotection against Traumatic Brain Injury via Suppressing Ferroptosis. ACS Chemical Neuroscience. 2022 23. Shan G, Bi G, Zhao G, et al.Inhibition of PKA/CREB1 pathway confers sensitivity to ferroptosis in non-small cell lung cancer.Respiratory Research.2023, 24(1): 1-15. 24. Liu S, Tao Y, Wu S, et al.Sanguinarine chloride induces ferroptosis by regulating ROS/BACH1/HMOX1 signaling pathway in prostate cancer.Chinese Medicine.2024, 19(1): 1-18. 25. Ying Z, Yin M, Zhu Z, et al.Iron Stress Affects the Growth and Differentiation of Toxoplasma gondii.International Journal of Molecular Sciences.2024, 25(5): 2493. 26. Bi G, Liang J, Bian Y, et al.Polyamine-mediated ferroptosis amplification acts as a targetable vulnerability in cancer.Nature Communications.2024, 15(1): 2461.

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剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

剂量

mg/kg

每只动物体重

给药体积

μL

动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

计算重置

计算结果如下:

工作液浓度: mg/ml;

母液配置方法: mg 药物溶于 μL DMSO (母液浓度为 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 μL DMSO 主液，加入 μL PEG300，混匀澄清，再加 μL Tween 80，混匀澄清，再加 μL ddH₂O, 混匀澄清。

备注:

要按顺序从左向右依次添加助溶剂。可配合物理方法，如涡流、超声波或热水浴使之帮助溶解。

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到，包括如何准备库存溶液，如何存储产品，以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Deferoxamine Mesylate 138-14-7 Apoptosis Autophagy Chromatin/Epigenetic Metabolism Neuroscience Others Mitophagy Beta Amyloid Ferroptosis HIF/HIF Prolyl-Hydroxylase HIFs neovascularization TAMSCs desferrioxamine B diabetes mellitus Akt PKB Protein kinase B SH-SY5Y Hypoxia-inducible factors Deferoxamine Desferrioxamine B mesylate DFO Desferrioxamine B Mesylate Inhibitor MEFs cancer Alzheimer’s disease HIF-PH Reactive Oxygen Species BMMSCs inhibit DFOM 去铁铵 COVID-19 甲磺酸去铁胺 inhibitor

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Deferoxamine Mesylate

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溶解度

溶液配制表

计算器

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参考文献

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剂量换算

体内实验配液计算器

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