Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.
产品描述 | Daun02 is the topoisomerase inhibitor Daunorubicin prodrug. |
体外活性 | Daun02 is converted by β-galactosidase to Daunorubicin, which has been shown to reduce Ca2+-dependent action potentials in neuroblastoma cells [1]. Daun02 is a good substrate for β-galactosidase (β-gal) and it also is a topoisomerase inhibitor [2]. The concentration of Daun02 producing 50% (EC50) decrease in cell viability is 0.5 μM, 1.5 μM, and 3.5 μM for T47-D, Panc02, and MCF-7, respectively [3]. |
体内活性 | Daun02 is a good substrate for β-gal (Km and Vmax: 0.37 mM; protein: 8.6 μmol/min/mg). Daun02 is 79% bound to plasma protein compares to 94% for Daunomycin, at a concentration of 10 μM [3]. |
分子量 | 884.79 |
分子式 | C41H44N2O20 |
CAS No. | 290304-24-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (113.02 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.1302 mL | 5.6511 mL | 11.3021 mL | 28.2553 mL |
5 mM | 0.226 mL | 1.1302 mL | 2.2604 mL | 5.6511 mL | |
10 mM | 0.113 mL | 0.5651 mL | 1.1302 mL | 2.8255 mL | |
20 mM | 0.0565 mL | 0.2826 mL | 0.5651 mL | 1.4128 mL | |
50 mM | 0.0226 mL | 0.113 mL | 0.226 mL | 0.5651 mL | |
100 mM | 0.0113 mL | 0.0565 mL | 0.113 mL | 0.2826 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Daun02 290304-24-4 DNA Damage/DNA Repair Topoisomerase Daun-02 Inhibitor inhibitor inhibit