Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DL-Penicillamine (3-Sulfanylvaline) 是一种螯合剂,推荐用于去除威尔逊病患者体内多余的铜。 它仅存在于使用或服用该药物的个体中。它是青霉素类抗生素最具特征的降解产物。它被用作抗风湿药和威尔逊病的螯合剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 162 | 现货 | ||
10 mg | ¥ 265 | 现货 | ||
25 mg | ¥ 583 | 现货 | ||
50 mg | ¥ 874 | 现货 | ||
100 mg | ¥ 1,313 | 现货 | ||
500 mg | ¥ 2,750 | 现货 |
产品描述 | DL-Penicillamine (3-Sulfanylvaline) is a chelating agent recommended for the removal of excess copper in patients with Wilson's disease. DL-Penicillamine is only found in individuals that have used or taken this drug. It is the most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease. From in vitro studies which indicate that one atom of copper combines with two molecules of DL-penicillamine. DL-Penicillamine also reduces excess cystine excretion in cystinuria. This is done, at least in part, by disulfide interchange between DL-penicillamine and cystine, resulting in the formation of penicillamine-cysteine disulfide, a substance that is much more soluble than cysteine and is excreted readily. DL-Penicillamine interferes with the formation of cross-links between tropocollagen molecules and cleaves them when newly formed. The mechanism of action of DL-penicillamine in rheumatoid arthritis is unknown although it appears to suppress disease activity. Unlike cytotoxic immunosuppressants, DL-penicillamine markedly lowers IgM rheumatoid factor but produces no significant depression in absolute levels of serum immunoglobulins. Also unlike cytotoxic immunosuppressants which act on both, DL-penicillamine in vitro depresses T-cell activity but not B-cell activity. |
别名 | 3-Sulfanylvaline, DL-青霉胺 |
分子量 | 149.21 |
分子式 | C5H11NO2S |
CAS No. | 52-66-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 5 mM
DMSO: Insoluble
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O | 1 mM | 6.702 mL | 33.5098 mL | 67.0196 mL | 167.5491 mL |
5 mM | 1.3404 mL | 6.702 mL | 13.4039 mL | 33.5098 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
DL-Penicillamine 52-66-4 Microbiology/Virology Antibiotic 3-Sulfanylvaline DL-青霉胺 DL Penicillamine DLPenicillamine Inhibitor inhibitor inhibit