store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DAMGO (DAGO) 是一种阿片受体激动剂,Kd 值为 3.46 nM。它能够影响啮齿动物的运动活动,可作为镇痛剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 492 | 现货 | ||
2 mg | ¥ 616 | 现货 | ||
5 mg | ¥ 822 | 现货 | ||
10 mg | ¥ 1,390 | 现货 | ||
25 mg | ¥ 2,970 | 现货 | ||
50 mg | ¥ 4,130 | 现货 | ||
100 mg | ¥ 6,210 | 现货 | ||
500 mg | ¥ 12,500 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 929 | 现货 |
产品描述 | DAMGO (DAGO) is an opioid receptor agonist with the ability to affect the locomotive activity in rodents. Possible analgesic agent due to μ-opiod receptor interaction. |
靶点活性 | μ opioid receptor (Native):3.46±0.84 nM (Kd) |
体内活性 | (1) DAMGO inhibits GABAergic inputs in VTA-DA neurons at presynaptic sites; (2) effect of DAMGO on GABAergic inputs in VTA-DA neurons is inhibited by potassium channel blocker 4-aminopyridine (4-AP) and Gi protein inhibitor N-ethyl maleimide (NEM); (3) phospholipase A2 (PLA2) does not mediate the effect of DAMGO on GABAergic inputs in VTA-DA neurons, but mediates it in the periaqueductal gray (PAG); (4) multiple downstream signaling molecules of l receptors do not mediate the effect of DAMGO on GABAergic inputs in VTA-DA neurons. These results suggest that DAMGO depresses inhibitory synaptic transmission via l receptor-Gi protein-Kv channel pathway in VTA-DA neurons, but via l receptor-PLA2 pathway in PAG |
别名 | Dagol, DAGO, RX-783006 |
分子量 | 513.59 |
分子式 | C26H35N5O6 |
CAS No. | 78123-71-4 |
store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 33.33 mg/mL (64.90 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.9471 mL | 9.7354 mL | 19.4708 mL | 48.677 mL |
5 mM | 0.3894 mL | 1.9471 mL | 3.8942 mL | 9.7354 mL | |
10 mM | 0.1947 mL | 0.9735 mL | 1.9471 mL | 4.8677 mL | |
20 mM | 0.0974 mL | 0.4868 mL | 0.9735 mL | 2.4338 mL | |
50 mM | 0.0389 mL | 0.1947 mL | 0.3894 mL | 0.9735 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
DAMGO 78123-71-4 Endocrinology/Hormones GPCR/G Protein Neuroscience Opioid Receptor Dagol RX783006 μ-opioid receptor DAGO RX 783006 RX-783006 inhibit μ-OPR Inhibitor analgesic effect inhibitor