keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cyclosporine 是一种钙调神经磷酸酶通路抑制剂,用作免疫抑制剂以防止器官移植中的排斥反应。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 mg | ¥ 267 | 现货 | ||
25 mg | ¥ 428 | 现货 | ||
50 mg | ¥ 788 | 现货 | ||
100 mg | ¥ 1,160 | 现货 | ||
500 mg | ¥ 2,920 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 359 | 现货 |
产品描述 | Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. |
体外活性 | Cyclosporine induces phenotypic changes, including invasiveness of non-transformed cells, by a cell-autonomous mechanism. Cyclosporine treatment of adenocarcinoma cells results in striking morphological alterations, including membrane ruffling and numerous pseudopodial protrusions, increased cell motility, and anchorage-independent (invasive) growth. [1] Cyclosporine (cyclosporin A, CsA) has potent immunosuppressive properties, reflecting its ability to block the transcription of cytokine genes in activated T cells. Cyclosporine through formation of a complex with cyclophilin inhibits the phosphatase activity of calcineurin, which regulates nuclear translocation and subsequent activation of NFAT transcription factors. Cyclosporine also blocks the activation of JNK and p38 signaling pathways triggered by antigen recognition, making CsA a highly specific inhibitor of T cell activation. [2] Cyclosporine-mediated inhibition of the biliary excretion of MPAG by the Mrp2 transporter is the mechanism responsible for the interaction between Cyclosporine and mycophenolate mofetil (MMF). [3] Cyclosporine inhibits biochemical and morphological differentiation of skeletal muscle cells while having a minimal effect on proliferation. [4] |
体内活性 | Cyclosporine enhances tumour growth in immunodeficient SCID-beige mice. [1] Cyclosporine inhibits muscle regeneration after induced trauma in mice. [4] Cyclosporine peaks at 1 hour in blood, spleen, and kidney, with higher concentrations in spleen and kidney than in blood. [5] |
分子量 | 1202.61 |
分子式 | C62H111N11O12 |
CAS No. | 79217-60-0 |
keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 93 mg/mL (77.3 mM)
DMSO: 93 mg/mL (77.3 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
Ethanol / DMSO | 1 mM | 0.8315 mL | 4.1576 mL | 8.3152 mL | 20.7881 mL |
5 mM | 0.1663 mL | 0.8315 mL | 1.663 mL | 4.1576 mL | |
10 mM | 0.0832 mL | 0.4158 mL | 0.8315 mL | 2.0788 mL | |
20 mM | 0.0416 mL | 0.2079 mL | 0.4158 mL | 1.0394 mL | |
50 mM | 0.0166 mL | 0.0832 mL | 0.1663 mL | 0.4158 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Cyclosporine 79217-60-0 Metabolism Phosphatase Inhibitor inhibitor inhibit