首页Chromatin/EpigeneticEpigenetic Reader DomainCyclogalegenol
Cyclogalegenol
编号 T5575     别名: Astramembrangenin
CAS 78574-94-4     分子式 C30H50O5     分子量 490.72
靶点:
Astramembrangenin (Cycloastragenol) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus.Cycloastragenol (CAG) may have a novel therapeutic role in depression
纯度:99.92%
规格 库存 单价 数量
10 mg 上海现货 381.00
25 mg 上海现货 686.00
50 mg 上海现货 1029.00
100 mg 上海现货 1544.00
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生物活性

产品描述

Astramembrangenin (Cycloastragenol) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus.Cycloastragenol (CAG) may have a novel therapeutic role in depression

靶点活性

体外活性

Cyclogalegenol has important anti-inflammatory activity by inhibiting lymphocytes activation, proliferation and cytokines expression, this effect may be related to reduction of overall intracellular Ca2+ overload[1].

体内活性

oral administration of Cyclogalegenol for 7 days attenuated depression-like behavior in experimental mice.Cyclogalegenol stimulates telomerase activity in human neonatal keratinocytes and rat neuronal cells, and induces CREB activation followed by tert and bcl2 expression. Furthermore, Cyclogalegenol may have a novel therapeutic role in depression[2].

细胞实验

Mouse lymphocytes were obtained from spleens and subjected to Con A for 24h. Herein, the cells were treated with different concentrations of Cyclogalegenol. Cell viability was assayed by MTT. Pretreated by Cyclogalegenol and stimulated by Con A, the expression of CD69 and CD25, Th1/Th2/Th17 cytokines, cell cycle, proliferation and intracellular Ca2+ concentration ([Ca2+]i) were analyzed by flow cytometry[1].

动物实验

Mice were administered Cyclogalegenol 100 mg/kg, or water by oral gavage, or imipramine 15 mg/kg , a currently used tricyclic antidepressant, by intraperitoneal injection for 7 days as well as 45 min before testing. The forced swim test was performed as described previously , by placing a mouse in a glass cylinder (height: 30 cm, diameter: 15 cm) filled with water to a depth of 12 cm. Mice were tested in the cylinder for 6 min. The water was changed before testing another animal. All test sessions were recorded. Depression-like behavior was determined by observing the immobility of the mouse, where immobility is defined as when a mouse floats passively in the water with minimal movement to keep its head above the water. The total period of immobility during the last 4 min of the test session was determined[2].

化学信息

分子量

490.72

分子式

C30H50O5

CAS

78574-94-4

溶解度

DMSO: 98 mg/mL (199.71 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

store at -80°C

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 2.038 ml 10.189 ml 20.378 ml
5 mM 0.408 ml 2.038 ml 4.076 ml
10 mM 0.204 ml 1.019 ml 2.038 ml
50 mM 0.041 ml 0.204 ml 0.408 ml
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