生物活性
|
产品描述 |
Cyclizine Dihydrochloride is a histamine H1 antagonist. It is given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. |
|
靶点活性 |
H1 receptor, |
|
体外活性 |
Cyclizine可使食道下端括约肌张力增加,使曲折器官的灵敏度降低。Cyclizine可抑制中脑的的催吐中心。 |
|
体内活性 |
在健康成人志愿者体内,Cyclizine（50 mg,p.o.）给药2 h后,可达血药峰浓度约70 ng/mL,血浆消除半衰期约为20 h.Cyclizine（p.o.）30 min内可产生效果,1-2 h内达到最大作用效果,可持续4-6 h.与二苯甲基哌嗪相比,Cyclizine的抗组胺活性几乎可以忽略. |
化学信息
|
分子量 |
339.3 |
|
分子式 |
C18H24Cl2N2 |
|
CAS |
5897-18-7 |
|
溶解度 |
DMSO: 7 mg/mL (20.63 mM) Water: 62 mg/mL (182.7 mM) Ethanol: <1 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble ) |
|
储存条件 |
store at -80°C |
|
备注 |
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. |
配制溶液
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.947 ml | 14.736 ml | 29.472 ml |
| 5 mM | 0.589 ml | 2.947 ml | 5.894 ml |
| 10 mM | 0.295 ml | 1.474 ml | 2.947 ml |
| 50 mM | 0.059 ml | 0.295 ml | 0.589 ml |
产品操作手册
