Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cyamemazine, contains the phenothiazine chromophore, is a neuroleptic agent used as an anxiolytic. Cyamemazine is a potent 5-HT3 (Ki: 12 nM), 5-HT2A (Ki: 1.5 nM) and 5-HT2C (Ki: 75 nM) receptors antagonist with antipsychotic activity.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 1,080 | 5日内发货 | ||
25 mg | ¥ 5,990 | 5日内发货 | ||
50 mg | ¥ 7,790 | 5日内发货 | ||
100 mg | ¥ 11,900 | 5日内发货 |
产品描述 | Cyamemazine, contains the phenothiazine chromophore, is a neuroleptic agent used as an anxiolytic. Cyamemazine is a potent 5-HT3 (Ki: 12 nM), 5-HT2A (Ki: 1.5 nM) and 5-HT2C (Ki: 75 nM) receptors antagonist with antipsychotic activity. |
靶点活性 | 5-HT2C receptor:12 nM (ki), 5-HT2A receptor:1.5 nM (ki), 5-HT3 receptor:75 nM (ki) |
体外活性 | Cyamemazine shows a high affinity for dopamine receptors. It is consistent with its antipsychotic activity. At muscarinic receptors, the antagonist activity of Cyamemazine is consistent with its affinity for M1 (Ki: 13 nM), M2 (Ki: 42 nM), M3 (Ki: 321 nM), M4 (Ki: 12 nM), and M5 (Ki: 35 nM) receptors [1]. |
体内活性 | Cyamemazine act as an antagonist at the 5-HT3, 5-HT2C, and 5-HT2A receptors in 5-HT3-dependent contraction of isolated guinea pig ileum and bradycardic responses in rats in 5-HT2C-dependent phospholipase C stimulation in the rat brain membrane, and in 5-HT2A-dependent contraction of isolated rat aorta rings and isolated guinea pig trachea. Acute administration of low doses of Cyamemazine can reduces extracellular dopamine and metabolite concentrations in rat striatum [1]. |
分子量 | 323.46 |
分子式 | C19H21N3S |
CAS No. | 3546-03-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
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体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Cyamemazine 3546-03-0 GPCR/G Protein Neuroscience 5-HT Receptor Inhibitor inhibitor inhibit