Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Coniine hydrochloride 是一种聚酮化合物衍生的生物碱,对人类和动物有毒。它是一种烟碱型乙酰胆碱受体拮抗剂,可抑制神经系统。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,180 | 现货 | ||
5 mg | ¥ 2,420 | 现货 | ||
10 mg | ¥ 3,450 | 现货 | ||
25 mg | ¥ 5,620 | 现货 | ||
50 mg | ¥ 7,850 | 现货 | ||
100 mg | ¥ 10,500 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,720 | 现货 |
产品描述 | Coniine hydrochloride, a polyketide-derived alkaloid, is poisonous to humans and animals. It is a nicotinic acetylcholine receptor antagonist, which leads to inhibition of the nervous system. |
体外活性 | Reduction of γ-coniceine to coniine is facilitated by NADPH-dependent γ-coniceine reductase.?Although coniine is notorious for its toxicity, there is no consensus on its ecological roles, especially in the carnivorous pitcher plants where it occurs.?Lately there has been renewed interest in coniine's medical uses particularly for pain relief without an addictive side effect. |
分子量 | 163.7 |
分子式 | C8H18ClN |
CAS No. | 15991-59-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/ml (167.99 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 6.1087 mL | 30.5437 mL | 61.0874 mL | 152.7184 mL |
5 mM | 1.2217 mL | 6.1087 mL | 12.2175 mL | 30.5437 mL | |
10 mM | 0.6109 mL | 3.0544 mL | 6.1087 mL | 15.2718 mL | |
20 mM | 0.3054 mL | 1.5272 mL | 3.0544 mL | 7.6359 mL | |
50 mM | 0.1222 mL | 0.6109 mL | 1.2217 mL | 3.0544 mL | |
100 mM | 0.0611 mL | 0.3054 mL | 0.6109 mL | 1.5272 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Coniine hydrochloride 15991-59-0 Others Coniine Hydrochloride Inhibitor inhibitor inhibit