Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Clofilium tosylate 是一种钾通道阻滞剂,可诱导人早幼粒细胞白血病细胞凋亡,具有抗心律失常作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 253 | 现货 | ||
2 mg | ¥ 369 | 现货 | ||
5 mg | ¥ 582 | 现货 | ||
10 mg | ¥ 832 | 现货 | ||
25 mg | ¥ 1,960 | 现货 | ||
50 mg | ¥ 3,790 | 现货 | ||
100 mg | ¥ 5,450 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 717 | 现货 |
产品描述 | Clofilium tosylate is a potassium channel blocker, induces apoptosis on human promyelocytic leukemia (HL-60) cells. |
体外活性 | Treatment with 0-20 μM Clofilium inhibits viability and proliferation in a time- and concentration-dependent manner in HL-60 cells. Cell viability is significantly reduced in HL-60 cells treated with 2.5 μM to 10 μM Clofilium After 12 hours. Treatment with 10 μM Clofilium induces the proteolytic cleavage of inactive procaspase-3, p34 into its active form, p17 and subsequent cleavage of its substrate PARP.. However, the expression of Bcl-2 and Bax proteins does not change significantly[1]. |
分子量 | 510.17 |
分子式 | C28H44ClNO3S |
CAS No. | 92953-10-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (196.01 mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.9601 mL | 9.8007 mL | 19.6013 mL | 49.0033 mL |
5 mM | 0.392 mL | 1.9601 mL | 3.9203 mL | 9.8007 mL | |
10 mM | 0.196 mL | 0.9801 mL | 1.9601 mL | 4.9003 mL | |
20 mM | 0.098 mL | 0.49 mL | 0.9801 mL | 2.4502 mL | |
50 mM | 0.0392 mL | 0.196 mL | 0.392 mL | 0.9801 mL | |
100 mM | 0.0196 mL | 0.098 mL | 0.196 mL | 0.49 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Clofilium tosylate 92953-10-1 Membrane transporter/Ion channel Potassium Channel Clofilium inhibit Apoptosis Inhibitor KcsA Clofilium Tosylate inhibitor