Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cimiracemoside C (Cimicifugoside M) 是在升麻中发现的一种天然产物,可激活 AMPK 并具有抗糖尿病的潜在活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 656 | 现货 | ||
5 mg | ¥ 1,580 | 现货 | ||
10 mg | ¥ 2,380 | 现货 | ||
25 mg | ¥ 3,950 | 现货 | ||
50 mg | ¥ 5,730 | 现货 | ||
100 mg | ¥ 7,830 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,420 | 现货 |
产品描述 | Cimiracemoside C (Cimicifugoside M) is an active component of Cimicifuga racemosa. It activates AMPK and has the potential activity against diabetes. |
体外活性 | Ze 450 and some of its components (23-epi-26-deoxyactein, protopine and Cimiracemoside C) were investigated in vitro for their effects on AMP-activated protein kinase (AMPK) compared to metformin in HepaRG cells. Ze 450 (given orally (PO) and intraperitonally (IP)), metformin (PO) and controls were given over 7 days to 68 male ob/ob mice. Glucose and insulin concentrations were measured at baseline and during an oral glucose tolerance test (OGTT). Ze 450 and its components activated AMPK to the same extent as metformin. In mice, Ze 450 (PO/IP) decreased significantly average daily and cumulative weight gain, average daily food and water intake, while metformin had no effect. In contrast to metformin, PO Ze 450 virtually did not change maximum glucose levels during OGTT, however, prolonged elimination. Ze 450 administered PO and IP decreased significantly post-stimulated insulin, whereas metformin did not. HOMA-IR index of insulin resistance improved significantly after IP and PO Ze 450 and slightly after metformin. In summary, the results demonstrate that Ze 450 reduced significantly body weight, plasma glucose, improved glucose metabolism and insulin sensitivity in diabetic ob/ob mice. In vitro experiments suggest that part of the effects may be related to AMPK activation. |
别名 | 千层纸素A-7-0-Β-D-葡萄糖醛酸苷, Cimicifugoside M |
分子量 | 620.81 |
分子式 | C35H56O9 |
CAS No. | 256925-92-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6.21 mg/mL (10 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.6108 mL | 8.054 mL | 16.108 mL | 40.27 mL |
5 mM | 0.3222 mL | 1.6108 mL | 3.2216 mL | 8.054 mL | |
10 mM | 0.1611 mL | 0.8054 mL | 1.6108 mL | 4.027 mL |
中药材名称 | 中药材拉丁名 | 性 | 味 | 归经 |
总状升麻 | Cimicifuga racemosa | 温 | 辛, 甘 |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Cimiracemoside C 256925-92-5 Chromatin/Epigenetic PI3K/Akt/mTOR signaling AMPK AMP-activated protein kinase inhibit 千层纸素A-7-0-Β-D-葡萄糖醛酸苷 Inhibitor Cimicifugoside M inhibitor