首页 工具
登录
购物车
Cilazapril Monohydrate

Cilazapril Monohydrate

产品编号 T6444   CAS 92077-78-6
别名: Ro 31-2848 monohydrate, Justor, 西拉普利, 西拉普利水合物

Cilazapril Monohydrate (Justor) 是一种血管紧张素转化酶抑制剂,能够作用于高血压和充血性心力衰竭的研究。

TargetMol的所有产品和服务仅用于科学研究,不能被用于人体,我们也不向个人提供产品和服务。
Cilazapril Monohydrate Chemical Structure
Cilazapril Monohydrate, CAS 92077-78-6
规格 价格/CNY 货期 数量
25 mg ¥ 9,930 4-6周
1 mL * 10 mM (in DMSO) ¥ 7,480 4-6周
其他形式的 Cilazapril Monohydrate:
产品目录号及名称: Cilazapril Monohydrate (T6444)
点击图片重新获取验证码
该分子属于定制产品。陶术拥有优秀的合成团队,经验和能力,可以为您提供高性价比的产品。但由于客观因素,研发中会存在小概率合成不成功的情况,还请理解,如您有任何问题,欢迎咨询,我们将竭诚为您服务。
更多批次查询请联系客服
生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Cilazapril Monohydrate (Justor) is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure.
体外活性 BML-190 has 50-fold selectivity for CB2 receptors over CB1 receptors. In HEK-293 cells stably expressing the human CB2 receptor, BML-190 potentiates the forskolin-stimulated accumulation of cAMP. BML-190 reduces the basal levels of inositol phosphate production in cells expressing the CB2 receptor. 10 μM of BML-190 decreases inositol phosphates accumulation by 38%. [1] BML-190 is an aminoalkylindole. BML-190 is found to yield at least 15 metabolic products. [2] BML-190 diminishes LPS-induced NO and IL-6 production in a concentration-dependent manner. BML-190 also inhibits LPS-induced PGE2 production and COX-2 induction. [3]
体内活性 Cilazapril (1 mg/kg, daily) tends to decrease and the higher dose (10 mg/kg, daily) significantly decreases systolic blood pressure (SBP) in subtotal nephrectomized rats. Cilazapril attenuates the further development of protein uria in a dose-dependent manner in subtotal nephrectomized rats. Cilazapril attenuates the increase in plasma fibrinogen concentration and serum albumin concentration in a dose-dependent manner. Cilazapril reduces serum MCP-1 concentration in the nephrectomized rats. Cilazapril decreases hepatic fibrinogen synthesis through the alleviation of the local inflammatory process and the improvement of hypoalbuminemia. [1] Cilazapril normalizes systolic arterial pressure to 121 mm Hg (SD) in the treated SHR-SP rats. Cilazapril decreases systolic arterial pressure to a nearly normal level and prevents hypertensive retinal vascular changes, probably by improving endothelial function. [2] Cilazapril results in a marked decrease in the Kd of the renal arginine vasopressin (AVP) receptor and an increase in the plasma AVP level in the spontaneously hypertensive rat. [3] Cilazapril exerts a rapid, complete, and persistent antihypertensive effect in the spontaneously hypertensive rats (SHR) in vivo but has no effect on SAP in the normotensive Sprague-Dawley rat. Cilazapril treatment depresses heart performance (28-35%) in SHR but has no effect in the Sprague-Dawley rats. [4] Cilazapril decreases blood pressure to control values and reduces HW:BW in hyperthyroid rats. [5]
别名 Ro 31-2848 monohydrate, Justor, 西拉普利, 西拉普利水合物
分子量 435.51
分子式 C22H31N3O5·H2O
CAS No. 92077-78-6

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

Ethanol: 81 mg/mL (186 mM)

H2O: <1 mg/mL

DMSO: 81 mg/mL (186 mM)

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO 1 mM 2.2962 mL 11.4808 mL 22.9616 mL 57.404 mL
5 mM 0.4592 mL 2.2962 mL 4.5923 mL 11.4808 mL
10 mM 0.2296 mL 1.1481 mL 2.2962 mL 5.7404 mL
20 mM 0.1148 mL 0.574 mL 1.1481 mL 2.8702 mL
50 mM 0.0459 mL 0.2296 mL 0.4592 mL 1.1481 mL
100 mM 0.023 mL 0.1148 mL 0.2296 mL 0.574 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
=
X
X
X
=
X
=
/
g/mol

输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Sugimoto K, et al. J Pharmacol Sci, 2004, 94(1), 67-72. 2. Bhutto IA, et al. Life Sci, 1999, 64(3), PL27-39. 3. Nishida N, et al. Res Commun Chem Pathol Pharmacol, 1994, 84(2), 143-152. 4. Christe ME, et al. Am J Physiol, 1994, 267(5 Pt 2), H2050-2057. 5. Asahi T, et al. Thyroid, 2001, 11(11), 1009-1015.
Lisinopril CGP-42112 acetate ANGIOTENSIN IV TFA(12676-15-2(free base)) L162389 Trans-Tranilast Fimasartan Ramipril Losartan Carboxylic Acid

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% ddH2O
计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Cilazapril Monohydrate 92077-78-6 Endocrinology/Hormones RAAS Angiotensin-converting Enzyme (ACE) Ro 31-2848 monohydrate Justor 西拉普利 Inhibitor Ro 31-2848 Monohydrate 西拉普利水合物 Ro 31-2848 inhibit Cilazapril inhibitor

 

陶术
生物
TargetMol®中国区唯一合作伙伴
点击进入陶术生物官网陶术生物
联系我们
400-820-0310

上海市静安区江场三路238号8楼