Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ciglitazone (ADD 3878) 是一种强效和选择性的PPARγ激动剂(EC50:3μM)和口服降糖药。Ciglitazone 抑制th17细胞的增殖和分化,降低胰岛素水平、血管内皮生长因子的产生和血压,诱导胃癌细胞的细胞周期停止。Ciglitazone 能诱导负鼠肾上皮细胞的凋亡,激活p38 MAPK 和凋亡诱导因子(AIF)的核转位。 Ciglitazone 在肥胖症和高血糖症的动物模型中表现出降血糖活性。
产品描述 | Ciglitazone (ADD 3878) is a potent and selective PPARγ agonist (EC50: 3 μM) and oral hypoglycemic agent. Ciglitazone inhibits proliferation and differentiation of th17 cells, decreases insulin levels, vascular endothelial growth factor production and blood pressure, and induces cell cycle arrest in gastric cancer cells. Selegiline induces apoptosis in opossum kidney epithelial cells and activates nuclear translocation of p38 MAPK and apoptosis-inducing factor (AIF). Ciglitazone exhibits hypoglycaemic activity in animal models of obesity and hyperglycaemia. |
靶点活性 | PPARγ:3 μM(EC50) |
体外活性 | Ciglitazone (0-20 μM ; 24 hours) ciglitazone causes the generation of ROS and an increase in intracellular Ca2+ and induces apoptosis through a PPAR-independent mechanism.[4] |
体内活性 |
Ciglitazone (100 mg/kg/day ; 2 days ; C57BL/6J-ob/ob mice) elicits a drastic fall in blood glucose.[3]
Ciglitazone (100 mg/kg/day ; 41-44 days ; ob/ob mice) degranulation of islet beta-cells and increased pancreatic insulin content are observed.[3] |
别名 | Ciglitazona, U 63287, ADD3878, ADD-3878, U-63287, ADD 3878 |
分子量 | 333.45 |
分子式 | C18H23NO3S |
CAS No. | 74772-77-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (269.9 mM ), Sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.999 mL | 14.9948 mL | 29.9895 mL | 74.9738 mL |
5 mM | 0.5998 mL | 2.999 mL | 5.9979 mL | 14.9948 mL | |
10 mM | 0.2999 mL | 1.4995 mL | 2.999 mL | 7.4974 mL | |
20 mM | 0.1499 mL | 0.7497 mL | 1.4995 mL | 3.7487 mL | |
50 mM | 0.06 mL | 0.2999 mL | 0.5998 mL | 1.4995 mL | |
100 mM | 0.03 mL | 0.1499 mL | 0.2999 mL | 0.7497 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Ciglitazone 74772-77-3 Apoptosis DNA Damage/DNA Repair MAPK Metabolism p38 MAPK PPAR Ciglitazona U 63287 ADD3878 ADD-3878 U63287 U-63287 ADD 3878 Inhibitor inhibitor inhibit