Chebulinic acid

产品编号 TQ0184   CAS 18942-26-2
别名: 诃子林鞣酸

Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.

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Chebulinic acid结构式
Chebulinic acid , CAS 18942-26-2
规格 库存 价格/RMB 数量
1 mg 上海现货 1582.00
5 mg 上海现货 4817.00
10 mg 上海现货 7215.00
25 mg 上海现货 12987.00
50 mg 上海现货 19481.00
100 mg 上海现货 29221.00
200 mg 待询 43831.00
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纯度 98.91%
生物活性
化学信息
存储 & 溶解度
产品描述 Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.
体外活性 Chebulinic acid obviously inhibited HQ/Cu(II)- and H(2)O(2)/Cu(II)-mediated pBR322 DNA strand breaks. When MRC-5 cells were treated with HQ/Cu(II), the presence of Chebulinic acid inhibited HQ/Cu(II)-mediated double-strand breaks of genomic DNA [1].
体内活性 Chebulinic acid had no effect on KCl-induced aortic contraction, but irreversibly inhibited the contractile responses to phenylephrine in an apparently non-competitive manner. Chebulinic acid also inhibited contractile responses of rat aorta to 5-hydroxytryptamine and angiotensin II. 3. Chebulinic acid inhibited the binding of [3H]-prazosin to dog aortic microsomal membranes in a concentration-dependent manner with an IC50 value of 0.34 mmol/L [2].
别名 诃子林鞣酸
纯度 98.91%
分子量 956.68
分子式 C41H28O27
CAS No. 18942-26-2

存储

Powder: -20°C for 3 years

In solvent: -80°C for 6 months

溶解度

DMSO: Soluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

文献引用

参考文献
1. Zong-Chun Yi, et al. Chebulinic Acid and Tellimagrandin I Inhibit DNA Strand Breaks by hydroquinone/Cu(II) and H(2)O(2)/Cu(II), but Potentiate DNA Strand Breaks by H(2)O(2)/Fe(II). Toxicol In Vitro. Jun 2009; 23 (4), 667-73 2. Y Y Guan, et al. In Vitro Inhibitory Effects of Chebulinic Acid on the Contractile Responses of Cardiovascular Muscles. Clin Exp Pharmacol Physiol. Aug 1996 23 (8), 747-50 3. Mishra V et al. Anti-secretory and cyto-protective effects of chebulinic acid isolated from the fruits of Terminalia chebula on gastric ulcers. Phytomedicine. 2013 Apr 15;20(6):506-11.

相关化合物库

该产品包含在如下化合物库中:
Bioactive Compound Library Inhibitor Library Natural Product Library for HTS Stem Cell Differentiation Compound Library Ion Channel Inhibitor Library Antibiotics Library Selected Plant-Sourced Compound Library Polyphenolic Natural Product Library Chinese Pharmacopoeia Natural Product Library Anti-Bacterial Compound Library Drug-induced Liver Injury (DILI) Compound Library Traditional Chinese Medicine Monomer Library Anti-Breast Cancer Compound Library Anti-Pancreatic Cancer Compound Library Anti-Fibrosis Compound Library

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