Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ch55 (3,5-Di-tert-butylchalcone)是HL60细胞分化的有效诱导剂(EC50 = 200 nM),与RAR-α和RAR-β受体显示出高亲和力。Ch55可用于有关癌症的研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 429 | 现货 | ||
5 mg | ¥ 947 | 现货 | ||
10 mg | ¥ 1,490 | 现货 | ||
25 mg | ¥ 2,970 | 现货 | ||
50 mg | ¥ 4,390 | 现货 | ||
100 mg | ¥ 6,280 | 现货 | ||
500 mg | ¥ 12,800 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,060 | 现货 |
产品描述 | Ch55 (3,5-Di-tert-butylchalcone) is an effective inducer of the differentiation of HL60 cells (EC50 = 200 nM) and shows high affinity with RAR-α and RAR-β receptors. Ch55 can be used in studies about cancer. |
体外活性 | In rabbit tracheal epithelial cells, Ch55 inhibits type I transglutaminase activity (EC50 = 0.02 nM) and increases cholesterol sulfate levels (EC50 = 0.03 nM) thereby inhibiting squamous cell differentiation. Ch55 inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC50 = 1 nM) and induces cell differentiation of embryonic carcinoma F9 cells and melanoma S91 cells (EC50 = 0.26 and 0.5 nM). Ch55 shows a low affinity for cellular retinoic acid binding protein[1]. |
别名 | Ch-55, CH 55, 3,5-Di-tert-butylchalcone |
分子量 | 364.48 |
分子式 | C24H28O3 |
CAS No. | 110368-33-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40 mg/mL (109.7 mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.7436 mL | 13.7182 mL | 27.4363 mL | 68.5909 mL |
5 mM | 0.5487 mL | 2.7436 mL | 5.4873 mL | 13.7182 mL | |
10 mM | 0.2744 mL | 1.3718 mL | 2.7436 mL | 6.8591 mL | |
20 mM | 0.1372 mL | 0.6859 mL | 1.3718 mL | 3.4295 mL | |
50 mM | 0.0549 mL | 0.2744 mL | 0.5487 mL | 1.3718 mL | |
100 mM | 0.0274 mL | 0.1372 mL | 0.2744 mL | 0.6859 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Ch55 110368-33-7 Metabolism Retinoid Receptor Ch-55 CH 55 3,5-Di-tert-butylchalcone Inhibitor inhibitor inhibit