Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Centrinone-B (LCR-323) is a potent and highly selective inhibitor of PLK4 (Ki: 0.59 nM).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 785 | 5日内发货 | ||
25 mg | ¥ 6,430 | 6-8周 | ||
50 mg | ¥ 8,360 | 6-8周 | ||
100 mg | ¥ 12,600 | 6-8周 |
产品描述 | Centrinone-B (LCR-323) is a potent and highly selective inhibitor of PLK4 (Ki: 0.59 nM). |
靶点活性 | Aurora A:1239 nM (ki), Aurora B:5597.14 nM (ki), PLK4 (G95L):497.53 nM (ki), PLK4:0.59 nM (ki) |
体外活性 | Centrinone-B (0-200 nM) significantly decreases cell viability of PLK4-centriole conjunction melanoma cell lines except for p53 mutant SK-MEL-28, and this effect is via inhibition of PLK4. Centrinone-B slightly binds to Aurora A and Aurora B (Kis: 1239 nM and 5597.14 nM). Centrinone-B exhibits >1000-fold selectivity for Plk4 over Aurora A/B in vitro and does not affect cellular Aurora A or B substrate phosphorylation at concentrations that deplete centrosomes [1]. Inhibition of PLK4 by Centrinone-B also induces apoptosis in human melanoma cell lines [2]. |
别名 | LCR-323 |
分子量 | 631.67 |
分子式 | C27H27F2N7O5S2 |
CAS No. | 1798871-31-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (39.58 mM), Sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.5831 mL | 7.9155 mL | 15.8311 mL | 39.5776 mL |
5 mM | 0.3166 mL | 1.5831 mL | 3.1662 mL | 7.9155 mL | |
10 mM | 0.1583 mL | 0.7916 mL | 1.5831 mL | 3.9578 mL | |
20 mM | 0.0792 mL | 0.3958 mL | 0.7916 mL | 1.9789 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Centrinone-B 1798871-31-4 Cell Cycle/Checkpoint Chromatin/Epigenetic Aurora Kinase LCR-323 Centrinone B LCR323 LCR 323 CentrinoneB Inhibitor inhibitor inhibit