Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cefoperazone (Medocef) 是一种半合成的头孢菌素,有抗菌活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
500 mg | ¥ 198 | 现货 | ||
1 g | ¥ 328 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 226 | 现货 |
产品描述 | Cefoperazone (Medocef) binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. It can inhibit rMrp2-mediated [3H]E217βG uptake (IC50: 199 μM). |
靶点活性 | rMrp2-mediated [3H]E217βG uptake:199 μM |
体内活性 | After treatment of Cefoperazone (2 g, i.v.), levels in serum range from 202μg/mL to 375 μg/mL depending on the period of drug administration. After intramuscular injection of 2 g of Cefoperazone, the mean peak serum level is 111 μg/mL at 1.5 hours. At 12 hours after dosing, mean serum levels are still 2 to 4 μg/mL. Cefoperazone is 90% bound to serum proteins. |
别名 | 头孢哌酮, Cefob, Medocef |
分子量 | 645.67 |
分子式 | C25H27N9O8S2 |
CAS No. | 62893-19-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 91 mg/mL(140.9 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.5488 mL | 7.7439 mL | 15.4878 mL | 38.7195 mL |
5 mM | 0.3098 mL | 1.5488 mL | 3.0976 mL | 7.7439 mL | |
10 mM | 0.1549 mL | 0.7744 mL | 1.5488 mL | 3.8719 mL | |
20 mM | 0.0774 mL | 0.3872 mL | 0.7744 mL | 1.936 mL | |
50 mM | 0.031 mL | 0.1549 mL | 0.3098 mL | 0.7744 mL | |
100 mM | 0.0155 mL | 0.0774 mL | 0.1549 mL | 0.3872 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Cefoperazone 62893-19-0 Microbiology/Virology Antibacterial Antibiotic inhibit 头孢哌酮 Inhibitor Cefob Medocef Bacterial inhibitor