store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cefdinir (FK-482) 是头孢菌素类中的一种半合成广谱抗生素,对几种革兰氏阴性和革兰氏阳性细菌引起的感染有效。它可研究耳,鼻窦,喉咙和皮肤的常见细菌感染。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
500 mg | ¥ 415 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 131 | 现货 |
产品描述 | Cefdinir (FK-482) is a semi-synthetic, broad-spectrum antibiotic in the third generation of the cephalosporin class, proven effective for common bacterial infections of the ear, sinus, throat and skin. |
体外活性 | Cefdinir, a new oral 2-amino-5-thiazolyl cephalosporin, inhibits the luminol-amplified chemiluminescence (LACL) response of human neutrophils stimulated by PMA but not opsonized zymosan, in a concentration-dependent but not time-dependent manner. Cefdinir inhibits LACL generation in cell-free systems consisting of Water2, NaI, and either horseradish peroxidase or amyeloperoxidase-containing neutrophil extract. Cefdinir impairs LACL response induced by the calcium ionophore A23187 and FMLP, and this impairment is increased in cytochalasin B-treated neutrophils. Cefdinir directly inhibits the activity of myeloperoxidase-containing neutrophil extract released into the extracellular medium during neutrophil stimulation by soluble mediators, but has no effect on that released into the phagolysosome during phagocytosis. [1] Cefdinir demonstrates excellent activity against a wide range of gram-positive and gram-negative bacteria. Cefdinir is resistant to a broad variety of β-lactamases and exhibits a β-lactam stability profile generally better than those observed with cefaclor and cefuroxime. Cefdinir elimination is primarily mediated by the kidney. Cefdinir interacts with the dipeptide transporters PEPT1 and PEPT2. Cefdinir tubular reabsorption is substantial, that Cefdinir tubular secretion is inhibitable by probenecid, and that this secretion is probably mediated by the renal organic anion secretory pathway. [2] |
激酶实验 | Topoisomerase II activity assay: Nuclear extracts are prepared, and nuclei are isolated. The activity of topoisomerase II is calculated from the percentage of decatenation obtained. Tritiated kinoplast DNA (KDNA 0.22 μg) is used as a substrate. Etoposide and topoisomerase II are incubated for 30 min at 37 ℃ and are stopped with 1% sodium dodecyl sulfate (SDS) and proteinase K (100 μg/mL). The percentages of decatenation and inhibition of topoisomerase II by Etoposide are obtained. |
别名 | FK-482, 头孢地尼, CI-983, PD 134393 |
分子量 | 395.41 |
分子式 | C14H13N5O5S2 |
CAS No. | 91832-40-5 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 73 mg/mL (184.6 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.529 mL | 12.6451 mL | 25.2902 mL | 63.2255 mL |
5 mM | 0.5058 mL | 2.529 mL | 5.058 mL | 12.6451 mL | |
10 mM | 0.2529 mL | 1.2645 mL | 2.529 mL | 6.3226 mL | |
20 mM | 0.1265 mL | 0.6323 mL | 1.2645 mL | 3.1613 mL | |
50 mM | 0.0506 mL | 0.2529 mL | 0.5058 mL | 1.2645 mL | |
100 mM | 0.0253 mL | 0.1265 mL | 0.2529 mL | 0.6323 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Cefdinir 91832-40-5 Metabolism Microbiology/Virology Antibiotic Antibacterial Glutathione Peroxidase FK-482 cephalosporin CI 983 PD-134393 Inhibitor Bacterial Gram-positive Gram-negative PD134393 inhibit CI983 FK 482 头孢地尼 bacteria CI-983 FK482 PD 134393 inhibitor