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Cefdinir

Cefdinir

产品编号 T0133   CAS 91832-40-5
别名: FK-482, 头孢地尼, CI-983, PD 134393

Cefdinir (FK-482) 是头孢菌素类中的一种半合成广谱抗生素,对几种革兰氏阴性和革兰氏阳性细菌引起的感染有效。它可研究耳,鼻窦,喉咙和皮肤的常见细菌感染。

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Cefdinir Chemical Structure
Cefdinir, CAS 91832-40-5
规格 价格/CNY 货期 数量
500 mg ¥ 415 现货
1 mL * 10 mM (in DMSO) ¥ 131 现货
其他形式的 Cefdinir:
产品目录号及名称: Cefdinir (T0133)
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纯度: 99.94%
纯度: 99.89%
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生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Cefdinir (FK-482) is a semi-synthetic, broad-spectrum antibiotic in the third generation of the cephalosporin class, proven effective for common bacterial infections of the ear, sinus, throat and skin.
体外活性 Cefdinir, a new oral 2-amino-5-thiazolyl cephalosporin, inhibits the luminol-amplified chemiluminescence (LACL) response of human neutrophils stimulated by PMA but not opsonized zymosan, in a concentration-dependent but not time-dependent manner. Cefdinir inhibits LACL generation in cell-free systems consisting of Water2, NaI, and either horseradish peroxidase or amyeloperoxidase-containing neutrophil extract. Cefdinir impairs LACL response induced by the calcium ionophore A23187 and FMLP, and this impairment is increased in cytochalasin B-treated neutrophils. Cefdinir directly inhibits the activity of myeloperoxidase-containing neutrophil extract released into the extracellular medium during neutrophil stimulation by soluble mediators, but has no effect on that released into the phagolysosome during phagocytosis. [1] Cefdinir demonstrates excellent activity against a wide range of gram-positive and gram-negative bacteria. Cefdinir is resistant to a broad variety of β-lactamases and exhibits a β-lactam stability profile generally better than those observed with cefaclor and cefuroxime. Cefdinir elimination is primarily mediated by the kidney. Cefdinir interacts with the dipeptide transporters PEPT1 and PEPT2. Cefdinir tubular reabsorption is substantial, that Cefdinir tubular secretion is inhibitable by probenecid, and that this secretion is probably mediated by the renal organic anion secretory pathway. [2]
激酶实验 Topoisomerase II activity assay: Nuclear extracts are prepared, and nuclei are isolated. The activity of topoisomerase II is calculated from the percentage of decatenation obtained. Tritiated kinoplast DNA (KDNA 0.22 μg) is used as a substrate. Etoposide and topoisomerase II are incubated for 30 min at 37 ℃ and are stopped with 1% sodium dodecyl sulfate (SDS) and proteinase K (100 μg/mL). The percentages of decatenation and inhibition of topoisomerase II by Etoposide are obtained.
别名 FK-482, 头孢地尼, CI-983, PD 134393
分子量 395.41
分子式 C14H13N5O5S2
CAS No. 91832-40-5

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 73 mg/mL (184.6 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.529 mL 12.6451 mL 25.2902 mL 63.2255 mL
5 mM 0.5058 mL 2.529 mL 5.058 mL 12.6451 mL
10 mM 0.2529 mL 1.2645 mL 2.529 mL 6.3226 mL
20 mM 0.1265 mL 0.6323 mL 1.2645 mL 3.1613 mL
50 mM 0.0506 mL 0.2529 mL 0.5058 mL 1.2645 mL
100 mM 0.0253 mL 0.1265 mL 0.2529 mL 0.6323 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Labro MT, et al. J Immunol,1994, 152(5), 2447-2455. 2. Lepsy CS, et al. Antimicrob Agents Chemother,2003, 47(2), 689-696.
Lefamulin acetate Cefoperazone Gatifloxacin Ronidazole SulfadiMethoxine sodium Artemether Procaine penicillin G Isavuconazole

相关化合物库

该产品包含在如下化合物库中:
药物功能重定位化合物库 肝脏毒性化合物库 β-内酰胺类化合物库 抗生素库 抗感染化合物库 儿童药物库 ReFRAME 相关化合物库 已知活性化合物库 FDA上市及药典收录分子库 FDA 上市药物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% ddH2O
计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Cefdinir 91832-40-5 Metabolism Microbiology/Virology Antibiotic Antibacterial Glutathione Peroxidase FK-482 cephalosporin CI 983 PD-134393 Inhibitor Bacterial Gram-positive Gram-negative PD134393 inhibit CI983 FK 482 头孢地尼 bacteria CI-983 FK482 PD 134393 inhibitor

 

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