Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Carmofur (HCFU) 是 5-氟尿嘧啶的衍生物,是一种抗肿瘤药物。它是一种酸性神经酰胺酶抑制剂,用于治疗乳腺癌和结直肠癌。它抑制 SARS-CoV-2主要蛋白酶,还抑制 Vero E6 细胞 SARS-CoV-2,EC50为 24.3 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
50 mg | ¥ 310 | 现货 | ||
100 mg | ¥ 434 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 478 | 现货 |
产品描述 | Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopathy. |
靶点活性 | AC:29 ± 5 nM |
体外活性 | Carmofur is one of the masked compounds of 5-FU, which was modified for more potent antineoplastic activity and less toxicity. Carmofur is converted in vivo into 5-FU directly or via intermetabolites, such as 1-(carboxypentylcarbamoyl)-5-fluorouracil and/or 1-(carboxypropylcarbomoyl)-5-fluorouraci. Carmofur and its metabolites gradually accumulate in the brain during continuous administration and are removed very slowly. Carmofur has potent neurotoxicity which can produce severe leucoencephalopathy resembling methotrexate leucoencephalopathy both clinically and on brain CT, together with a cerebellar syndrome similar to that following 5-FU neurotoxicity. [1] |
别名 | HCFU, 卡莫氟 |
分子量 | 257.26 |
分子式 | C11H16FN3O3 |
CAS No. | 61422-45-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 49 mg/mL (190.5 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 10 mg/mL (38.87 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / Ethanol | 1 mM | 3.8871 mL | 19.4356 mL | 38.8712 mL | 97.178 mL |
5 mM | 0.7774 mL | 3.8871 mL | 7.7742 mL | 19.4356 mL | |
10 mM | 0.3887 mL | 1.9436 mL | 3.8871 mL | 9.7178 mL | |
20 mM | 0.1944 mL | 0.9718 mL | 1.9436 mL | 4.8589 mL | |
DMSO | 50 mM | 0.0777 mL | 0.3887 mL | 0.7774 mL | 1.9436 mL |
100 mM | 0.0389 mL | 0.1944 mL | 0.3887 mL | 0.9718 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Carmofur 61422-45-5 Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology Nucleoside Antimetabolite/Analog Virus Protease SARS-CoV DNA/RNA Synthesis antineoplastic SARS coronavirus inhibit derivative protease HCFU 卡莫氟 Inhibitor Mpro 5-fluorouracil inhibitor