Carebastine
编号 T10680
CAS 90729-42-3
分子式
C32H37NO4
分子量
499.64
靶点：
H1 receptor;
Carebastine, the active metabolite of Ebastine, is an antagonist of the histamine H1 receptor.
生物活性
|
产品描述 |
Carebastine, the active metabolite of Ebastine, is an antagonist of the histamine H1 receptor. |
|
靶点活性 |
H1 receptor, |
|
体外活性 |
Carebastine inhibits VEGF-induced HPAEC and HUVEC proliferation, migration, and angiogenesis in a dose-dependent manner [1]. Carebastine suppresses the expression of macrophage migration inhibitory factor [2]. |
|
体内活性 |
化学信息
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分子量 |
499.64 |
|
分子式 |
C32H37NO4 |
|
CAS |
90729-42-3 |
|
溶解度 |
（ < 1 mg/ml refers to the product slightly soluble or insoluble ) |
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储存条件 |
store at -80°C |
|
备注 |
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. |
配制溶液
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.001 ml | 10.007 ml | 20.014 ml |
| 5 mM | 0.4 ml | 2.001 ml | 4.003 ml |
| 10 mM | 0.2 ml | 1.001 ml | 2.001 ml |
| 50 mM | 0.04 ml | 0.2 ml | 0.4 ml |
参考文献
- 1. De Luisi A, et al. Anti-angiogenic activity of carebastine: a plausible mechanism affecting airway remodelling. Eur Respir J. 2009 Oct;34(4):958-66.
- 2. Zhao Y, et al. Carebastine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor. Clin Exp Dermatol. 2008 Nov;33(6):785-7.
产品操作手册
