Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Captopril (SA333) 是一种含巯基的,具有口服活性的血管紧张素转换酶(ACE)抑制剂 ,IC50=0.025 μM,广泛应用于高血压和充血性心力衰竭的研究。Captopril 也是NDM-1抑制剂,IC50=7.9 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 186 | 现货 | ||
50 mg | ¥ 272 | 现货 | ||
100 mg | ¥ 354 | 现货 | ||
200 mg | ¥ 496 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 398 | 现货 |
产品描述 | Captopril (SA333) is a potent and specific inhibitor of peptidyl-dipeptidase A. It blocks the conversion of angiotensin I to angiotensin II, a vasoconstrictor and important regulator of arterial blood pressure. |
靶点活性 | ACE:6 nM |
激酶实验 | Binding assay: Cells are plated in 24-well plates and cultured until confluence. Before the experiment, the cells are washed three times with 0.5 mL per well of DMEM at room temperature. After removal of the medium, 400 μL binding DMEM is added and the plate is then left for 15 min at 37 ℃. For saturation binding assays cells are incubated with increasing concentrations [3H]Candesartan (final concentrations between 0.15 nM and 15 nM) in a final volume of 0.5 mL at 37 ℃ for 5 min to 180 min. For competition binding assays 50 μL of buffer or 50 μL of buffer containing increasing concentrations of unlabelled Candesartan is added. After 30 min, 50 μL of buffer containing [3H]Candesartan (final concentration 1.1 nM) or [3H]Candesartan (final concentration 1.0 nM) is added, and the cells are further incubated for 30 min at 37 ℃. |
别名 | SQ 14225, 甲巯丙脯酸, 卡托普利, SQ-14534, SA333 |
分子量 | 217.29 |
分子式 | C9H15NO3S |
CAS No. | 62571-86-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 21.7 mg/mL (100 mM)
DMSO: 21.7 mg/mL (100 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O / DMSO | 1 mM | 4.6021 mL | 23.0107 mL | 46.0214 mL | 115.0536 mL |
5 mM | 0.9204 mL | 4.6021 mL | 9.2043 mL | 23.0107 mL | |
10 mM | 0.4602 mL | 2.3011 mL | 4.6021 mL | 11.5054 mL | |
20 mM | 0.2301 mL | 1.1505 mL | 2.3011 mL | 5.7527 mL | |
50 mM | 0.092 mL | 0.4602 mL | 0.9204 mL | 2.3011 mL | |
100 mM | 0.046 mL | 0.2301 mL | 0.4602 mL | 1.1505 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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