Capsaicin

产品编号: T1062 别名:

8-Methyl-N-vanillyl-trans-6-nonenamide,Qutenza,天然辣椒素,Zostrix,(E)-Capsaicin,Vanilloid,辣椒素

Capsaicin 是一种TRPV1激动剂，是辣椒中的活性成分，具有减轻疼痛、神经保护、抗氧化、抗炎和抗癌作用。

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CAS：404-86-4

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生物活性化学信息储存和溶解度信息参考文献引用文献

产品描述

Capsaicin is an active component of chili peppers. It selectively binds to TRPV1 which is a heat-activated calcium channel. Capsaicin causes the channel to open below 37 °C This is why capsaicin is linked to the sensation of heat.

体外活性

Capsaicin is an agonist of transient receptor potential vanilloid subtype 1 (TRPV1), which is expressed in nociceptive sensory neurons and a range of secretory epithelia, including salivary glands. Capsaicin activates TRPV1, which modulates the permeability of tight junctions (TJ) by regulating the expression and function of putative intercellular adhesion molecules in an ERK-dependent manner[2]. Capsaicin is found to inhibit the growth and proliferation of FaDu cells in a dose- and time-dependent manner. Cells treated with 50, 100, 200, and 300 μM Capsaicin show an augmented decrease in cell growth as the Capsaicin dose increases. In addition, the percentage of viable cells decreases as the incubation time increases. The observed IC50 value is around 150 μM[3].

体内活性

Capsaicin (CAP)-treated animals (Group IV) show increased DNA fragmentation suggesting apoptosis when compare with B(a)P-induced lung cancer-bearing animals (Group II) that show reduced DNA fragmentation. CAP-treated Group IV animals show markedly increased expressions of p53, Bax and caspase-3 with remarkable decrease in the levels of anti-apoptotic protein Bcl-2, when compare with B(a)P-administered lung cancer animals of Group II[4]. Capsaicin causes a dose-dependent reduction of tear secretion in female Wistar/ST rats. Significant effects are observed at doses of 20, 50 and 100?mg/kg. In addition, Capsaicin also causes corneal lesions, and significant effects are observed at doses of 50 and 100?mg/kg[5].

细胞实验

Capsaicin is dissolved in DMSO and stored, and then diluted with appropriate medium before use[3]. FaDu cells are plated at a density of 1×105 cells/well on 24-well plate. After overnight growth, the cells are treated with various concentrations of Capsaicin (0 μM, 50 μM, 100 μM, 150 μM, 200 μM, 250 μM, 300 μM, and 350 μM) for 24, 48 and 72 hours, with medium replacement every 24 hours. At the end of treatment, 30 μL of the tetrazolium compound MTT, and 270 μL of fresh medium are added. After further incubation for 4 hours at 37°C, 200 μL of 0.1 N HCl in 10% SDS is added into each well to dissolve the tetrazolium crystals. Finally, the absorbance at a wavelength of 540 nm is recorded using an ELISA plate reader[3].

Cas No.

404-86-4

分子式

C18H27NO3

分子量

305.418

别名

8-Methyl-N-vanillyl-trans-6-nonenamide;Qutenza;天然辣椒素;Zostrix;(E)-Capsaicin;Vanilloid;辣椒素;Capsaicin

参考文献

[1]Wang J, et al. Anti-inflammatory and retinal protective effects of capsaicin on ischaemia-induced injuries through the release of endogenous somatostatin. Clin Exp Pharmacol Physiol. 2017 Jul;44(7):803-814.[2]McNamara FN, et al. Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1). Br J Pharmacol. 2005 Mar;144(6):781-90.[3]Kagawa Y, et al. Investigation of capsaicin-induced superficial punctate keratopathy model due to reduced tear secretion in rats. Curr Eye Res. 2013 Jul;38(7):729-35.[4]Le TD, et al. Capsaicin-induced apoptosis of FaDu human pharyngeal squamous carcinoma cells. Yonsei Med J. 2012 Jul 1;53(4):834-41.[5]Xia J, Gu L, Guo Y, et al. Gut Microbiota Mediates the Preventive Effects of Dietary Capsaicin Against Depression-Like Behavior Induced by Lipopolysaccharide in Mice[J]. Frontiers in Cellular and Infection Microbiology. 2021, 11.[6]Shin YH, et al. The Effect of Capsaicin on Salivary Gland Dysfunction. Molecules. 2016 Jun 25;21(7).[7]Tang K, Zhang X, Guo Y. Identification of the dietary supplement capsaicin as an inhibitor of Lassa virus entry[J]. Acta Pharmaceutica Sinica B. 2020.[8]Anandakumar P, et al. Capsaicin provokes apoptosis and restricts benzo(a)pyrene induced lung tumorigenesis in Swiss albino mice. Int Immunopharmacol. 2013 Jun 6;17(2):254-259.

引用文献

[1]Lu J, Zhou W, Dou F, et al. TRPV1 sustains microglial metabolic reprogramming in Alzheimer's disease. EMBO reports. 2021, 22(6): e52013.[2]Lu J, Wang C, Cheng X, et al. A breakdown in microglial metabolic reprogramming causes internalization dysfunction of α-synuclein in a mouse model of Parkinson’s disease. Journal of Neuroinflammation. 2022, 19(1): 1-21 [3]Wang C, Huang W, Lu J, et al. TRPV1-Mediated Microglial Autophagy Attenuates Alzheimer's Disease-Associated Pathology and Cognitive Decline. Frontiers in Pharmacology. 2021, 12: 763866-763866.[4]Wang C, Huang W, Lu J, et al. TRPV1-Mediated Microglial Autophagy Attenuates Alzheimer’s Disease-Associated Pathology and Cognitive Decline. Frontiers in Pharmacology. 2021, 12 [5]Tang K, Zhang X, Guo Y. Identification of the dietary supplement capsaicin as an inhibitor of Lassa virus entry. Acta Pharmaceutica Sinica B. 2020 [6]Xia J, Gu L, Guo Y, et al. Gut Microbiota Mediates the Preventive Effects of Dietary Capsaicin Against Depression-Like Behavior Induced by Lipopolysaccharide in Mice. Frontiers in Cellular and Infection Microbiology. 2021, 11.

储存和溶解度

DMSO:15.3 mg/mL(50 mM)
keep away from direct sunlight
Powder: -20°C for 3 years
In solvent: -80°C for 2 years

剂量换算 Capsaicin 404-86-4

对于各种应用，安全且有效的用药剂量是很有必要的了解更多

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第一步：请输入动物实验的基本信息

剂量 mg/kg

每只动物体重 g

给药体积 ul

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第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

% DMSO +

% +

% Tween 80 +

% ddH₂O

% DMSO +

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计算结果如下:

工作液浓度: mg/ml;

母液配置方法: mg 药物溶于 μL DMSO (母液浓度为 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 μL DMSO 主液，加入 μL PEG300，混匀澄清，再加 μL Tween 80，混匀澄清，再加 μL ddH₂O, 混匀澄清。

备注:

要按顺序从左向右依次添加助溶剂。可配合物理方法，如涡流、超声波或热水浴使之帮助溶解。

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已知质量的化合物在一定体积内形成的溶液的浓度

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在抑制剂处理说明中可以找到您可能遇到的问题的答案。主题包括如何准备储备溶液，如何存储产品以及基于细胞的测定和动物实验需要特别注意的问题。

Keywords

8-Methyl-N-vanillyl-trans-6-nonenamide Capsaicin Qutenza 天然辣椒素 Zostrix (E)-Capsaicin Vanilloid 辣椒素 404-86-4

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Capsaicin

8-Methyl-N-vanillyl-trans-6-nonenamide,Qutenza,天然辣椒素,Zostrix,(E)-Capsaicin,Vanilloid,辣椒素

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