Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CTX1 is a small molecule activator of p53.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 9,700 | 6-8周 | ||
50 mg | ¥ 12,600 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 |
产品描述 | CTX1 is a small molecule activator of p53. |
体外活性 | CTX1 can induce p53 protein levels in the p53 mutant cell line, HT29 and it also induces significant p53-dependent cell death preferentially in HdmX-expressing cells as compared to cells in which p53 is inactivated by Hdm2 overexpression or p53 is knocked down using p53 targeting shRNA. It is also found that CTX1 shows potent activity (LD50 ~1 μM) as a single agent on primary AML patient samples in a similar fashion to AML cell lines. After CTX1(16 h) treatment in HCT116 p53-wild-type cells, there is a decrease in S phase from 23% to 3% while HCT116 p53-null cells exhibit a reduction in S phase from 34% to 28%. The combination of low doses of CTX1 and nutlin-3 leads to a significant enhancement of apoptosis in p53-wildtype, but not p53-null cells. |
体内活性 | Mice treated with CTX1 alone or in combination with nutlin-3 has a significantly increased survival time (p<0.0001). In this model system, CTX1 even as a single agent significantly enhances the survival of mice. |
分子量 | 234.26 |
分子式 | C14H10N4 |
CAS No. | 501935-96-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
CTX1 501935-96-2 Apoptosis p53 CTX-1 CTX 1 Inhibitor inhibitor inhibit