首页Chromatin/EpigeneticEpigenetic Reader DomainCPI-637
CPI-637
编号 T6811     别名: CPI637, CPI 637,
CAS 1884712-47-3     分子式 C22H22N6O     分子量 386.45
靶点: BRD4; CBP; EP300;
CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor.
纯度:99.9%
规格 库存 单价 数量
2 mg 上海现货 410.00
5 mg 上海现货 647.00
10 mg 上海现货 934.00
25 mg 上海现货 2033.00
50 mg 上海现货 3690.00
100 mg 上海现货 6888.00
1 mL * 10 mM (in DMSO) 上海现货 647.00
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生物活性

产品描述

CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor.

靶点活性

BRD4,11μM

CBP,0.03μM

EP300,0.051μM

体外活性

CPI-637 inhibits MYC expression in AMO-1 cells (EC50=0.60 μM)[1].

体内活性

细胞实验

AMO-1 cells (DSMZ) were plated at 20,000 cells/well in 96-well plates in Iscove's Modified Dulbecco's Medium supplemented with 10% fetal calf serum. Cells were treated for 6 h with a dose titration of CPI-637 starting from a 5 µM top concentration. After 6 h, cells were lysed and processed for QuantiGene Plex expression analysis and data were collected on a MAGPIX multiplex Luminex instrument.(Only for Reference)

细胞系: AMO-1 cells

化学信息

分子量

386.45

分子式

C22H22N6O

CAS

1884712-47-3

溶解度

DMSO: 26 mg/mL (67.3 mM)

Ethanol: <1 mg/mL

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

store at -80°C

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 2.588 ml 12.938 ml 25.877 ml
5 mM 0.518 ml 2.588 ml 5.175 ml
10 mM 0.259 ml 1.294 ml 2.588 ml
50 mM 0.052 ml 0.259 ml 0.518 ml
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