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CC-401 Hydrochloride

产品编号 T5833 CAS 1438391-30-0

别名: CC401 HCl

CC-401 Hydrochloride (CC401 HCl) 是 JNK 抑制剂(Ki= 25~50 nM)。

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CC-401 Hydrochloride, CAS 1438391-30-0

规格	价格/CNY	货期
1 mg	￥ 315	现货
5 mg	￥ 745	现货
10 mg	￥ 1,160	现货
25 mg	￥ 2,320	现货
50 mg	￥ 3,560	现货
100 mg	￥ 5,130	现货
500 mg	￥ 10,500	现货
1 mL * 10 mM (in DMSO)	￥ 818	现货

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其他形式的 CC-401 Hydrochloride:

CC 401 dihydrochloride
询价
CC-401
询价

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纯度: 98%

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生物活性

化学信息

存储 & 溶解度

参考文献

相关产品

产品描述	CC-401 Hydrochloride (CC401 HCl) is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor (Ki of 25 to 50 nM.)with potential antineoplastic activity.
靶点活性	JNK:25-50 nM (Ki)
体外活性	CC-401 in combination with chemotherapy demonstrates synergism in colon cancer cell lines, although synergy is not always hypoxia specific.?A more detailed analysis focused on HT29 and SW620 (responsive), and HCT116 (nonresponsive) lines.?In HT29 and SW620 cells, CC-401 treatment results in greater DNA damage in the sensitive cells.
体内活性	In vivo, potentiation of bevacizumab, oxaliplatin, and the combination by JNK inhibition was confirmed in HT29-derived mouse xenografts, in which tumor growth delay was greater in the presence of CC-401.?Finally, stable introduction of a dominant negative JNK1, but not JNK2, construct into HT29 cells rendered them more sensitive to oxaliplatin under hypoxia, suggesting differing input of JNK isoforms in cellular responses to chemotherapy.
动物实验	To assess the efficacy of JNK signaling inhibition by CC-401 in anti-angiogenic and oxaliplatin combination therapy in a mouse xenograft model, adult (8-10 weeks of age) female severe combined immunodeficient mice (C.B.17 SCID) were used.?To generate tumors, HT29 cells (1 × 10^6 cells) were injected subcutaneously into the left flank of the mice.?When the tumors reached approximately 200 mm^3, mice were divided into eight groups (eight mice per group) for treatment with bevacizumab , oxaliplatin, CC401, and the appropriate combinations of bevacizumab, oxaliplatin and CC-401.?Mice in the bevacizumab treatment group received 5 mg/kg of bevacizumab by intraperitoneal injection every 3 days for 21 days.?The oxaliplatin treatment group was injected intraperitoneally with 5 mg/kg oxaliplatin per week for 2 weeks.?The CC-401 treatment group was injected intraperitoneally 25 mg/kg for every 3 days.?The combination treatment groups received bevacizumab (every 3 days, 5 mg/kg), oxaliplatin (weekly for 2 weeks, 5 mg/kg), and CC-401 (every 3 days, 25 mg/kg).?The control group received saline intraperitoneally.?Tumor volume and body weight were measured every 3 days.?Tumor volume was calculated using the formula V = AB^2/2, where A is the largest diameter and B is the smallest diameter.?Tumor growth delay was calculated as the difference in the time for control and treated tumors to grow from 200 to 800 mm^3.?For tumor growth delay calculations, mice were continued to receive treatments till the tumor volume reached 800 mm^3.?For immunohistochemistry mice were sacrificed after treatments on day 9 for tumor processing and staining.

别名	CC401 HCl
分子量	424.93
分子式	C22H25ClN6O
CAS No.	1438391-30-0

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 100 mg/mL (235.33 mM)

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.3533 mL	11.7666 mL	23.5333 mL	58.8332 mL
	5 mM	0.4707 mL	2.3533 mL	4.7067 mL	11.7666 mL
	10 mM	0.2353 mL	1.1767 mL	2.3533 mL	5.8833 mL
	20 mM	0.1177 mL	0.5883 mL	1.1767 mL	2.9417 mL
	50 mM	0.0471 mL	0.2353 mL	0.4707 mL	1.1767 mL
	100 mM	0.0235 mL	0.1177 mL	0.2353 mL	0.5883 mL

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

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容积

分子量

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容积 (起始)

浓度 (终)

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参考文献

1. Vasilevskaya I A , Selvakumaran M , Hierro L C , et al. Inhibition of JNK Sensitizes Hypoxic Colon Cancer Cells to DNA-Damaging Agents[J]. Clinical Cancer Research, 2015:1078-0432.CCR-15-0352.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

剂量

mg/kg

每只动物体重

给药体积

μL

动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

计算重置

计算结果如下:

工作液浓度: mg/ml;

母液配置方法: mg 药物溶于 μL DMSO (母液浓度为 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 μL DMSO 主液，加入 μL PEG300，混匀澄清，再加 μL Tween 80，混匀澄清，再加 μL ddH₂O, 混匀澄清。

备注:

要按顺序从左向右依次添加助溶剂。可配合物理方法，如涡流、超声波或热水浴使之帮助溶解。

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到，包括如何准备库存溶液，如何存储产品，以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

CC-401 Hydrochloride 1438391-30-0 MAPK JNK CC 401 Hydrochloride CC-401 Inhibitor CC401 Hydrochloride CC 401 CC401 inhibit CC401 HCl inhibitor

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CC-401 Hydrochloride

存储

溶解度

溶液配制表

计算器

输入分子式，点击计算，可计算出产品的分子量。

参考文献

相关产品

相关化合物库

剂量换算

体内实验配液计算器

技术支持

Keywords