Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CBR-5884 是一种磷酸甘油酸脱氢酶抑制剂,IC50为 33 μM。 它抑制癌细胞中的丝氨酸合成,选择性地抑制黑素瘤和乳腺癌细胞系的增殖,对具有高丝氨酸生物合成活性的癌细胞系有选择性毒性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 287 | 现货 | ||
5 mg | ¥ 453 | 现货 | ||
10 mg | ¥ 745 | 现货 | ||
25 mg | ¥ 1,630 | 现货 | ||
50 mg | ¥ 2,730 | 现货 | ||
100 mg | ¥ 3,970 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 490 | 现货 |
产品描述 | CBR-5884 is an selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis. Biochemical characterization of the inhibitor revealed that it was a noncompetitive inhibitor that showed a time-dependent onset of inhibition and disrupted the oligomerization state of PHGDH |
靶点活性 | PHGDH:33 μM |
体外活性 | CBR-5884 (15 or 30 μM; 3-5 days) selectively inhibits breast cancer lines that have a high propensity for serine synthesis. CBR-5884 (15 or 30 μM; 3-5 days) also selectively inhibits the proliferation of melanoma. |
分子量 | 336.39 |
分子式 | C14H12N2O4S2 |
CAS No. | 681159-27-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 47 mg/mL (139.72 mM), sonification is recommended.
H2O: < 0.1 mg/mL (insoluble)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.9727 mL | 14.8637 mL | 29.7274 mL | 74.3185 mL |
5 mM | 0.5945 mL | 2.9727 mL | 5.9455 mL | 14.8637 mL | |
10 mM | 0.2973 mL | 1.4864 mL | 2.9727 mL | 7.4318 mL | |
20 mM | 0.1486 mL | 0.7432 mL | 1.4864 mL | 3.7159 mL | |
50 mM | 0.0595 mL | 0.2973 mL | 0.5945 mL | 1.4864 mL | |
100 mM | 0.0297 mL | 0.1486 mL | 0.2973 mL | 0.7432 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
CBR-5884 681159-27-3 Metabolism Others Dehydrogenase inhibit Inhibitor CBR5884 CBR 5884 inhibitor