store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bz 423 是一种有效的免疫调节剂,通过激活 Bax 和 Bak 来诱导线粒体外膜通透和细胞色素 c 释放来诱导细胞凋亡。Bz 423 在狼疮小鼠模型中显示出部分活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 468 | 现货 | ||
5 mg | ¥ 788 | 现货 | ||
10 mg | ¥ 1,280 | 现货 | ||
25 mg | ¥ 2,960 | 现货 | ||
50 mg | 待询 | 8-10周 | ||
1 mL * 10 mM (in DMSO) | ¥ 872 | 现货 |
产品描述 | Bz 423 is a potent immunomodulator that induces apoptosis by activating Bax and Bak to induce mitochondrial outer membrane permeabilization and cytochrome c release.Bz 423 shows partial activity in a mouse model of lupus. |
体外活性 | Bz-423 triggers the activation of Bax and Bak without concurrently activating ASK1/JNK in Ramos cells[2]. The induction of apoptosis by Bz-423 in Ramos cells relies on superoxide, and it elicits a heightened superoxide response in these cells, resulting in the swift demise of Ramos B cells. In MEFs, Bz-423 rapidly elevates superoxide levels within 1 hour, with the extent of the increase depending on the concentration. In Ramos cells, Bz-423-induced superoxide generation instigates the activation of Bax and Bak, mediated by alterations in Mcl-1 expression and the functional activation of BH3-only proteins[1]. |
别名 | BZ48 |
分子量 | 440.92 |
分子式 | C27H21ClN2O2 |
CAS No. | 216691-95-1 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (181.44 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.268 mL | 11.3399 mL | 22.6799 mL | 56.6996 mL |
5 mM | 0.4536 mL | 2.268 mL | 4.536 mL | 11.3399 mL | |
10 mM | 0.2268 mL | 1.134 mL | 2.268 mL | 5.67 mL | |
20 mM | 0.1134 mL | 0.567 mL | 1.134 mL | 2.835 mL | |
50 mM | 0.0454 mL | 0.2268 mL | 0.4536 mL | 1.134 mL | |
100 mM | 0.0227 mL | 0.1134 mL | 0.2268 mL | 0.567 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Bz 423 216691-95-1 Apoptosis BCL BZ-48 BZ48 BZ 48 Inhibitor inhibitor inhibit