Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Buflomedil hydrochloride (Fonzylane) 是一种血管扩张剂,可用于外周动脉疾病引发的一系列症状。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
100 mg | ¥ 441 | 现货 | ||
200 mg | ¥ 548 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 356 | 现货 |
产品描述 | Buflomedil hydrochloride (Fonzylane), a vasodilator, is used in therapy of claudication or the symptoms of the peripheral arterial disease. |
体外活性 | Buflomedil enhances intracellular cAMP levels in human keratinocytes, either secondary to adenyl-cyclase stimulation (BC) or phosphodiesterase inhibition (PTX). Buflomedil diminishes release of TPA-induced TNF-alpha and IL-8 in keratinocytes; in the case of IL-8, this inhibition may occur to transcriptional level. At the micromolar level, Buflomedil notably inhibits epinephrine-induced aggregation. Buflomedil leads to a weak inhibition of collagen- and ADP-induced aggregation. Buflomedil inhibits grainy secretion and the interaction of fibrinogen with its receptor on platelet. the capillary perfusion is improved by Buflomedil hypochloride in such related situations, evoking a possible effect upon neutrophils. Buflomedil Completely inhibits adhesion of histamine related neutrophil (flow system) and partially inhibits adhesion after IL-1-4 hours (flow and stable systems). Buflomedil lowers the hypoxia-induced neutrophil adhesion and expression of P-selectin at the surface of endothelial cells. |
别名 | Buflomedil HCl, Fonzylane, Loftyl, 盐酸丁咯地尔, 丁咯地尔盐酸盐 |
分子量 | 343.85 |
分子式 | C17H26ClNO4 |
CAS No. | 35543-24-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 7 mg/mL (20.35 mM)
H2O: 63 mg/mL (183.2 mM)
DMSO: 29 mg/mL (84.3 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
Ethanol / H2O / DMSO | 1 mM | 2.9082 mL | 14.5412 mL | 29.0824 mL | 72.7061 mL |
5 mM | 0.5816 mL | 2.9082 mL | 5.8165 mL | 14.5412 mL | |
10 mM | 0.2908 mL | 1.4541 mL | 2.9082 mL | 7.2706 mL | |
20 mM | 0.1454 mL | 0.7271 mL | 1.4541 mL | 3.6353 mL | |
H2O / DMSO | 50 mM | 0.0582 mL | 0.2908 mL | 0.5816 mL | 1.4541 mL |
H2O | 100 mM | 0.0291 mL | 0.1454 mL | 0.2908 mL | 0.7271 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Buflomedil hydrochloride 35543-24-9 GPCR/G Protein Neuroscience Adrenergic Receptor Buflomedil inhibit Buflomedil HCl Fonzylane Inhibitor Loftyl 盐酸丁咯地尔 Buflomedil Hydrochloride 丁咯地尔盐酸盐 inhibitor