Borrelidin (Treponemycin) is a bacterial and eukaryal threonyl-tRNA synthetase inhibitor. It is a macrolide antibiotic isolated from Streptomyces rochei.
Borrelidin is an inhibitor of Cdc28/Cln2 of the budding yeast (IC50: 24 μM) . Borrelidin is a potent angiogenesis inhibitor (IC50: 0.8 nM) and induces apoptosis of the tube-forming cells. Borrelidin has strong antimalarial activities (IC50s: 1.9 nM and 1.8 nM against K1 and FCR3 strains of Plasmodium falciparum) .