首页Chromatin/EpigeneticEpigenetic Reader DomainBisdemethoxycurcumin
Bisdemethoxycurcumin
编号 TL0007     别名: Didemethoxycurcumin, Curcumin III
CAS 24939-16-0     分子式 C19H16O4     分子量 308.33
靶点:
Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α,25-dihydroxy vitamin D3 to stimulate amyloid-β clearance by macrophages (optimal stimulation at 100 nM BDMC) [1]. More stable than curcumin in physiological media, BDMC suppresses proliferation of cancer cells [2]. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits LPS induction of iNOS expression [3].
纯度:99.34%
规格 库存 单价 数量
5 mg 上海现货 328.00
1 mL * 10 mM (in DMSO) 上海现货 328.00
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生物活性

产品描述

Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α,25-dihydroxy vitamin D3 to stimulate amyloid-β clearance by macrophages (optimal stimulation at 100 nM BDMC) [1]. More stable than curcumin in physiological media, BDMC suppresses proliferation of cancer cells [2]. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits LPS induction of iNOS expression [3].

靶点活性

体外活性

体内活性

化学信息

分子量

308.33

分子式

C19H16O4

CAS

24939-16-0

溶解度

Ethanol: 5 mg/mL

DMSO: 10 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

store at -80°C

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 3.243 ml 16.216 ml 32.433 ml
5 mM 0.649 ml 3.243 ml 6.487 ml
10 mM 0.324 ml 1.622 ml 3.243 ml
50 mM 0.065 ml 0.324 ml 0.649 ml
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