首页 GPCR/G Protein Histamine Receptor Bilastine
Bilastine
编号 T4250     别名: Bilaxten, Bilaxten
CAS 202189-78-4     分子式 C28H37N3O3     分子量 463.62
靶点: H1 receptor; H1 receptor(in guinea-pig cerebellum);
Bilastine is a novel new-generation antihistamine that is highly selective for the H1 histamine receptor, has a rapid onset and prolonged duration of action.
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规格 库存 单价 数量
5 mg 上海现货 722.00
25 mg 上海现货 2223.00
50 mg 上海现货 3927.00
100 mg 上海现货 5958.00
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生物活性

产品描述

Bilastine is a novel new-generation antihistamine that is highly selective for the H1 histamine receptor, has a rapid onset and prolonged duration of action.

靶点活性

H1 receptor,

H1 receptor(in guinea-pig cerebellum),

体外活性

Bilastine has a highly selective affinity for the H1-receptor but a very low affinity for 30 other tested receptors. It isn't obvious inhibitory against bradykinin, serotonin, muscarinic M3-receptors, leukotriene D4, calcium, α1-adrenoceptors, β2-adrenoceptors, and H2- and H3- receptors.

体内活性

In patients with allergic rhinoconjunctivitis, Bilastine is efficacious in all nasal symptoms including obstruction and in eye symptoms. In the fasting state, Bilastine is quickly absorbed, but the absorption is slowed when it is taken with food or fruit juice.

化学信息

分子量

463.62

分子式

C28H37N3O3

CAS

202189-78-4

溶解度

DMSO: 2.2 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

store at -80°C

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 2.157 ml 10.785 ml 21.569 ml
5 mM 0.431 ml 2.157 ml 4.314 ml
10 mM 0.216 ml 1.078 ml 2.157 ml
50 mM 0.043 ml 0.216 ml 0.431 ml
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  • 经典已知活性库
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