Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bifluranol (BX341) 具有抗雄激素活性,在体内实验中显示出显著的抗前列腺活性,可用于治疗良性前列腺增生 (BPH)。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 3,260 | 现货 | ||
5 mg | ¥ 8,160 | 现货 | ||
10 mg | ¥ 10,800 | 现货 | ||
25 mg | ¥ 16,300 | 现货 | ||
50 mg | ¥ 21,800 | 现货 | ||
100 mg | ¥ 29,700 | 现货 |
产品描述 | Bifluranol (BX341) has anti-androgenic activity and has shown significant anti-prostatic activity in in vivo studies for the treatment of benign prostatic hyperplasia (BPH). |
体内活性 |
Bifluranol has been studied for its absorption, distribution, and excretion in mouse, rat, ferret, and dog. Following oral administration, Bifluranol is readily absorbed, but its blood concentrations are low due to hepatic uptake and biliary excretion. After the intravenous administration of [3H]Bifluranol at doses of 200 μg/kg in rats and 60 μg/kg in ferrets, the blood concentrations of 3H decline rapidly during the first 2 to 3 hours. The decrease is more rapid in females (18 min for rats, 30 min for ferrets) than in males (1.0 h for rats, 1.4 h for ferrets). This initial rapid decline is followed by a much slower decrease (40 h for rats, 20 h for ferrets) to concentrations at 96 hours of less than 15 ng Bifluranol equivalents mL-1 (rat) or 1 ng Bifluranol equivalents mL-1 (ferret)[1]. |
别名 | BX341 |
分子量 | 292.32 |
分子式 | C17H18F2O2 |
CAS No. | 34633-34-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (307.88 mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.4209 mL | 17.1045 mL | 34.2091 mL | 85.5227 mL |
5 mM | 0.6842 mL | 3.4209 mL | 6.8418 mL | 17.1045 mL | |
10 mM | 0.3421 mL | 1.7105 mL | 3.4209 mL | 8.5523 mL | |
20 mM | 0.171 mL | 0.8552 mL | 1.7105 mL | 4.2761 mL | |
50 mM | 0.0684 mL | 0.3421 mL | 0.6842 mL | 1.7105 mL | |
100 mM | 0.0342 mL | 0.171 mL | 0.3421 mL | 0.8552 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Bifluranol 34633-34-6 Endocrinology/Hormones Androgen Receptor BX341 BX 341 BX-341 Inhibitor inhibitor inhibit