Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Biapenem (CLI 86815) 是不经肠道的广谱碳青霉烯抗生素。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 268 | 现货 | ||
10 mg | ¥ 400 | 现货 | ||
25 mg | ¥ 721 | 现货 | ||
50 mg | ¥ 1,090 | 现货 | ||
100 mg | ¥ 1,530 | 现货 |
产品描述 | Biapenem (CLI 86815) is a 1-beta-methylcarbapenem antibiotic with a wide range of antibacterial activity. Biapenem has similar antibacterial activity to that of imipenem, but is more stable against human renal dehydropeptidase-I and with less neurotoxicity. |
体外活性 | Biapenem has activity comparable to those of Imipenem and Meropenem against all groups of anaerobes with MICs for 90% of the strains tested of 0.06 to 2 mg/mL. Biapenem is more active than ampicillin-sulbactam, ticarcillin-clavulanate, piperacillin, cefoxitin, cefotaxime, and ceftriaxone. Biapenem is also active against all of the B. capillosus, Prevotella, Clostridium, and Eubacterium strains and anaerobic cocci tested. [1] Biapenem shows broad antibacterial activity against both Gram-positive and Gram-negative clinical isolates. [2] Biapenem is found to be approximately as active as imipenem, inhibiting 90% of isolates of most species at concentrations within one dilution of the MIC of imipenem for 90% of the isolates. [3] |
体内活性 | Biapenem results in significantly fewer viable bacteria than in the lungs of control mice. Biapenem prevents the progression of lung inflammation, including alveolar neutrophil infiltration and hemorrhage. Biapenem significantly prolongs survival and reduces the number of viable bacteria in a murine model of VAP caused by P. aeruginosa. [4] |
别名 | CLI 86815, 比阿培南, Biapenern, Omegacin, L 627, LJC 10627 |
分子量 | 350.39 |
分子式 | C15H18N4O4S |
CAS No. | 120410-24-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Insoluble
H2O: 10 mM
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O | 1 mM | 2.854 mL | 14.2698 mL | 28.5396 mL | 71.3491 mL |
5 mM | 0.5708 mL | 2.854 mL | 5.7079 mL | 14.2698 mL | |
10 mM | 0.2854 mL | 1.427 mL | 2.854 mL | 7.1349 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Biapenem 120410-24-4 Microbiology/Virology Antibacterial Antibiotic ωcin inhibit CLI86815 CLI-86815 CLI 86815 比阿培南 Biapenern Omegacin Bacterial LJC10627 LJC-10627 L 627 wcin L627 L-627 LJC 10627 Inhibitor inhibitor