store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Benzthiazide (Lemazide) 是长效利尿剂及抗高血压剂。它也是碳酸酐酶 9 的抑制剂,他对 CA9,CA2 和 CA1 的 Ki 分别为 8.0,8.8 和 10 nM。它对肿瘤细胞增殖具有抑制作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
100 mg | ¥ 136 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 312 | 现货 |
产品描述 | Benzthiazide (Lemazide) is used in the therapy of edema and hypertension. Like other thiazides, benzthiazide accelerates water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue. |
靶点活性 | Carbonic anhydrase I:10 nM (Ki), CA9:8.0 nM (Ki), Carbonic anhydrase II:8.8 nM (Ki) |
别名 | Aquatag, 苄噻嗪, Lemazide, Dihydrex |
分子量 | 431.94 |
分子式 | C15H14ClN3O4S3 |
CAS No. | 91-33-8 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (104.19 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.3151 mL | 11.5757 mL | 23.1514 mL | 57.8784 mL |
5 mM | 0.463 mL | 2.3151 mL | 4.6303 mL | 11.5757 mL | |
10 mM | 0.2315 mL | 1.1576 mL | 2.3151 mL | 5.7878 mL | |
20 mM | 0.1158 mL | 0.5788 mL | 1.1576 mL | 2.8939 mL | |
50 mM | 0.0463 mL | 0.2315 mL | 0.463 mL | 1.1576 mL | |
100 mM | 0.0232 mL | 0.1158 mL | 0.2315 mL | 0.5788 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Benzthiazide 91-33-8 Metabolism Carbonic Anhydrase Inhibitor Carbonate dehydratase Aquatag 苄噻嗪 Lemazide Dihydrex inhibit inhibitor