Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Benazepril hydrochloride (CGS 14824A HCl) 是一种血管紧张素转化酶(ACE)抑制剂,能够作用于高血压。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
200 mg | ¥ 365 | 现货 | ||
500 mg | ¥ 583 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 137 | 现货 |
产品描述 | Benazepril hydrochloride (CGS 14824A HCl) is an angiotensin-converting enzyme (ACE) inhibitor widely used in the therapy of hypertension. Benazepril hydrochloride is associated with a low rate of transient serum aminotransferase elevations and has been linked to rare instances of acute liver injury. |
体内活性 | Benazepril hydrochloride (3 or 10 mg/kg/d, p.o. for 14 days) dose-dependently inhibits the increase in the blood pressure caused by continuous norepinephrine (NE) infusion in spontaneously hypertensive rats (SHR) and suppresses in seizures induced by a monoamine oxidase inhibitor, tranylcypromine in NE infused SHR. [1] Benazepril hydrochloride (30 mg/kg p.o.) decreases the triglyceride and total cholesterol levels in normotensive rats. Benazepril hydrochloride (3 mg/kg s.c.) causes a significant decrease in aortic atherosclerosis without reducing hypercholesterolemia in cholesterol-fed rabbits. Benazepril hydrochloride (100 mg/kg p.o.) shows no effect on the urine volume and urinary excretion of electrolytes but decreases PSP excretion in normotensive rats. Benazepril hydrochloride (10 mg/kg p.o.) inhibits the increase in the excretion of urinary protein in DOCA/salt spontaneously hypertensive rats. [3] Benazepril Hydrochloride administration corrects systemic hypertension and significantly reduces angiotensin II and aldosterone in cats with experimentally induced or spontaneously occurring chronic renal failure. Benazepril hydrochloride administration reduces serum creatinine and urinary protein concentration in cat with experimentally induced or spontaneously occurring chronic renal failure. [4] Benazepril hydrochloride significantly decreases blood pressure, angiotensin II and aldosterone and, increases upon discontinuation of administration to the pre-administration levels in a canine remnant kidney model of chronic renal failure. [5] |
别名 | 盐酸贝那普利, CGS 14824A HCl, Benazepril HCl, CGS14824A |
分子量 | 460.95 |
分子式 | C24H29ClN2O5 |
CAS No. | 86541-74-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 46.1 mg/mL (100 mM)
H2O: 23.1 mg/mL (50 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / H2O | 1 mM | 2.1694 mL | 10.8472 mL | 21.6943 mL | 54.2358 mL |
5 mM | 0.4339 mL | 2.1694 mL | 4.3389 mL | 10.8472 mL | |
10 mM | 0.2169 mL | 1.0847 mL | 2.1694 mL | 5.4236 mL | |
20 mM | 0.1085 mL | 0.5424 mL | 1.0847 mL | 2.7118 mL | |
50 mM | 0.0434 mL | 0.2169 mL | 0.4339 mL | 1.0847 mL | |
DMSO | 100 mM | 0.0217 mL | 0.1085 mL | 0.2169 mL | 0.5424 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Benazepril hydrochloride 86541-74-4 Endocrinology/Hormones RAAS inhibit Benazepril Angiotensin-converting Enzyme (ACE) 盐酸贝那普利 CGS 14824A HCl Inhibitor Benazepril HCl Benazepril Hydrochloride CGS14824A inhibitor