Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bay 41-4109 less active enantiomer shows less activity than Bay 41-4109. BAY 41-4109 is a potent HBV inhibitor (IC50: 53 nM).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 2,840 | 待询 | ||
10 mg | ¥ 4,285 | 待询 | ||
50 mg | ¥ 12,785 | 待询 | ||
100 mg | ¥ 17,885 | 待询 | ||
200 mg | 待询 | 待询 | ||
500 mg | 待询 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,480 | 待询 |
Bay 41-4109 (less active enantiomer) 的其他形式现货产品:
产品描述 | Bay 41-4109 less active enantiomer shows less activity than Bay 41-4109. BAY 41-4109 is a potent HBV inhibitor (IC50: 53 nM). |
靶点活性 | HBV:53 nM |
体外活性 | BAY 41-4109 is able to both accelerate and misdirect capsid assembly in vitro. Preformed capsids are stabilized by BAY 41-4109, up to a ratio of one inhibitor molecule per two dimers [2]. In HepG2.2.15 cells, BAY 41-4109 is equally effective at inhibiting HBV DNA release and the cytoplasmic HBcAg level (IC50s: 32.6 and 132 nM). HBV DNA and HBcAg are inhibited in a dose-dependent manner [3]. |
体内活性 | BAY 41-4109 reduces viral DNA in the liver and in the plasma dose-dependently with efficacy comparable to 3TC. BAY 41 -4109 reduces the hepatitis B virus core antigen (HBcAg) in livers of HBV-transgenic mice. Pharmacokinetic studies in mice have shown rapid absorption, a bioavailability of 30%, and dose-proportional plasma concentrations, about 60% in rats and dogs [1]. BAY41-4109 inhibits virus production in vivo by a mechanism that targets the viral capsid [2]. |
分子量 | 395.76 |
分子式 | C18H13ClF3N3O2 |
CAS No. | 476617-51-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 37 mg/mL (93.49 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.5268 mL | 12.6339 mL | 25.2678 mL | 63.1696 mL |
5 mM | 0.5054 mL | 2.5268 mL | 5.0536 mL | 12.6339 mL | |
10 mM | 0.2527 mL | 1.2634 mL | 2.5268 mL | 6.317 mL | |
20 mM | 0.1263 mL | 0.6317 mL | 1.2634 mL | 3.1585 mL | |
50 mM | 0.0505 mL | 0.2527 mL | 0.5054 mL | 1.2634 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Bay 41-4109 (less active enantiomer) 476617-51-3 Microbiology/Virology HBV less active enantiomer Bay 41-4109 Bay 41 4109 (less active enantiomer) Bay 414109 (less active enantiomer) Inhibitor inhibitor inhibit