Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Basimglurant (CTEP Derivative) 是一种高效,选择性,可口服的 mGlu5负变构调节剂,Kd 值为1.1 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 542 | 现货 | ||
5 mg | ¥ 1,320 | 现货 | ||
10 mg | ¥ 2,120 | 现货 | ||
25 mg | ¥ 3,930 | 现货 | ||
50 mg | ¥ 6,220 | 现货 | ||
100 mg | ¥ 8,380 | 现货 | ||
500 mg | ¥ 16,700 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,450 | 现货 |
产品描述 | Basimglurant (CTEP Derivative) is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM). |
靶点活性 | mGlu5 receptor:1.1 nM (Kd) |
体外活性 | In competition binding experiments on human recombinant mGlu5, Basimglurant (RG7090) fully displaces [3H]-MPEP with a Ki of 35.6 nM and [3H]-ABP688 with a Ki of 1.4 nM. In HEK293 cells stably expressing human mGlu5, Basimglurant (RG7090) inhibits quisqualate induced Ca2+ mobilization with an IC50 of 7.0 nM and [3H]-inositolphosphate accumulation (IC50 of 5.9 nM). Basimglurant shows similar potencies in radioligand binding and functional assay on human and rodent mGlu5 receptor orthologues[1]. |
体内活性 | Basimglurant is selective and safe inhibitor of mGlu5 with good oral bioavailability and long half-life supportive of once-daily administration, good brain penetration, and high in vivo potency. Basimglurant has antidepressant properties which are corroborated by its functional magnetic imaging (fMRI) profile, as well as anxiolytic-like and antinociceptive features[1]. |
别名 | CTEP Derivative, RG7090 |
分子量 | 325.77 |
分子式 | C18H13ClFN3 |
CAS No. | 802906-73-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 33.33 mg/mL (102.31 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.0697 mL | 15.3483 mL | 30.6965 mL | 76.7413 mL |
5 mM | 0.6139 mL | 3.0697 mL | 6.1393 mL | 15.3483 mL | |
10 mM | 0.307 mL | 1.5348 mL | 3.0697 mL | 7.6741 mL | |
20 mM | 0.1535 mL | 0.7674 mL | 1.5348 mL | 3.8371 mL | |
50 mM | 0.0614 mL | 0.307 mL | 0.6139 mL | 1.5348 mL | |
100 mM | 0.0307 mL | 0.1535 mL | 0.307 mL | 0.7674 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Basimglurant 802906-73-6 Neuroscience GluR Inhibitor RG-7090 Metabotropic glutamate receptors mGluR inhibit CTEP Derivative RG7090 RG 7090 inhibitor