Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bacoside A3 是一种天然的三萜皂苷,是Bacopa monnieri 的主要活性成分之一,显示出神经保护活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 392 | 现货 | ||
5 mg | ¥ 950 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,650 | 现货 |
产品描述 | Bacoside A3 is one of the components of Bacopa monnieri (L.) Wettst. bacoside A with antioxidant potential. Bacoside A3 shows comparatively higher neuroprotective response analysed as higher cell viability and decreased intracellular ROS. |
体外活性 | The cytoprotective effects of individual bacoside A components were evaluated towards oxidative stressed neuronal cells. Bacoside A was screened for neuronal cell viability (MTT assay) and change in intracellular reactive oxygen species (ROS), anti-apoptotic properties and mitochondrial membrane potential (MMP) using fluorescence microscopy. Different bacoside A components showed decrease in N2a cell viability below 100 (%) after bacoside A concentration of 0.4 mg/ml. Further, cytoprotective effect of optimized dose of bacoside A was analysed for alleviating oxidative stressed, apoptosis and MMP in H2 O2 stressed neuronal cells. Results showed increase in MMP, and decrease in apoptotic induction, without much change in nuclear integrity in stressed neuronal cells. Results showed Bacoside A3 and bacopaside II have comparatively higher cytoprotective ability whilst isomer of bacopasponin C, bacopasaponin C and mixture showed comparatively less response[1] |
别名 | 苦艾素A3, 白花猪母菜甙 A3 |
分子量 | 929.1 |
分子式 | C47H76O18 |
CAS No. | 157408-08-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (64.58 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.0763 mL | 5.3816 mL | 10.7631 mL | 26.9078 mL |
5 mM | 0.2153 mL | 1.0763 mL | 2.1526 mL | 5.3816 mL | |
10 mM | 0.1076 mL | 0.5382 mL | 1.0763 mL | 2.6908 mL | |
20 mM | 0.0538 mL | 0.2691 mL | 0.5382 mL | 1.3454 mL | |
50 mM | 0.0215 mL | 0.1076 mL | 0.2153 mL | 0.5382 mL |
中药材名称 | 中药材拉丁名 | 性 | 味 | 归经 |
假马齿苋 | Bacopa monnieri (L.) Wettst. | - | ― |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Bacoside A3 157408-08-7 Immunology/Inflammation Membrane transporter/Ion channel Neuroscience ATPase ROS P-gp Inhibitor Bacoside A-3 Bacoside A 3 苦艾素A3 inhibit 白花猪母菜甙 A3 inhibitor