Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BPR1J-097 hydrochloride (1327167-19-0(free base)) 是一种新型小分子 FLT-3抑制剂(IC50=11±7 nM),具有很好的体内抗肿瘤活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 322 | 现货 | ||
2 mg | ¥ 580 | 现货 | ||
5 mg | ¥ 935 | 现货 | ||
10 mg | ¥ 1,530 | 现货 | ||
25 mg | ¥ 2,580 | 现货 | ||
50 mg | ¥ 3,830 | 现货 | ||
100 mg | ¥ 5,490 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,190 | 现货 |
产品描述 | BPR1J-097, a new-type small molecule FLT-3 inhibitor(IC50=11±7 nM), is with great anti-tumor activities in vivo. |
靶点活性 | FLT-3 D835Y:3 nM, FLT3:11±7 Nm, MOLM-13 and MV4-11 cells:21±7 and 46±14 nM |
体内活性 | In FLT3-driven AML murine xenograft models, BPR1J-097 inhibited FLT3/signal transducer and activator of transcription 5 phosphorylation and triggered apoptosis in FLT3-driven AML cells and pronounced dose-dependent tumour growth inhibition and regression. |
激酶实验 | Cells are treated with THZ531 for 6 hours.After treatment cells are washed 2-fold with cold PBS and then lysed in the following lysis buffer: Hepes(50 mM, pH 7.4), NaCl(150 mM), 1% Nonidet P40 substitute, EDTA(5 mM), DTT(1 mM), and protease/phosphatase cocktails.Lysates are treated with bio-THZ1 or bio-TH531 for pulldown overnight at 4°C. |
分子量 | 553.07 |
分子式 | C27H29ClN6O3S |
CAS No. | T4261 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5.53 mg/mL (10 mM), Sonification is recommended
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.8081 mL | 9.0404 mL | 18.0809 mL | 45.2022 mL |
5 mM | 0.3616 mL | 1.8081 mL | 3.6162 mL | 9.0404 mL | |
10 mM | 0.1808 mL | 0.904 mL | 1.8081 mL | 4.5202 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
BPR1J-097 hydrochloride (1327167-19-0(free base)) T4261 Angiogenesis Tyrosine Kinase/Adaptors FLT BPR1J 097 hydrochloride (1327167 19 0(free base)) BPR-1J-097 hydrochloride (1327167-19-0(free base)) BPR1J097 hydrochloride (1327167190(free base)) Inhibitor inhibitor inhibit