Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Boc-D-FMK 是一种可渗透细胞,不可逆的泛半胱天冬酶抑制剂。它抑制 TNF-α 诱导的细胞凋亡的IC50值为 39 µM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 477 | 现货 | ||
5 mg | ¥ 1,490 | 现货 | ||
10 mg | ¥ 2,230 | 现货 | ||
25 mg | ¥ 3,770 | 现货 | ||
50 mg | ¥ 5,420 | 现货 | ||
100 mg | ¥ 7,590 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,910 | 现货 |
产品描述 | Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 μM). |
体外活性 | Boc-D-fmk inhibits TNFα-stimulated reactive oxygen species (ROS) generation [1]. Boc-D-fmk (50 μM) prevents genistein-induced apoptosis of p815 cells. The release of mitochondrial apoptotic factors is inhibited by Boc-D-fmk [2]. |
体内活性 | Boc-D-FMK-fmk effectively attenuates the hepatocyte apoptosis in bile duct-ligated rats and may improve the survival rates after the endotoxin challenge [3]. Boc-D-FMK (single injection) results in longterm protection of MNs against root avulsion-induced death for more than 8 weeks and the Boc-D-FMK-treated MNs are able to regenerate their axons into an implanted PN graft and reinnervate the target muscle [4]. |
分子量 | 263.26 |
分子式 | C11H18FNO5 |
CAS No. | 634911-80-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (474.82 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.7985 mL | 18.9926 mL | 37.9853 mL | 94.9632 mL |
5 mM | 0.7597 mL | 3.7985 mL | 7.5971 mL | 18.9926 mL | |
10 mM | 0.3799 mL | 1.8993 mL | 3.7985 mL | 9.4963 mL | |
20 mM | 0.1899 mL | 0.9496 mL | 1.8993 mL | 4.7482 mL | |
50 mM | 0.076 mL | 0.3799 mL | 0.7597 mL | 1.8993 mL | |
100 mM | 0.038 mL | 0.1899 mL | 0.3799 mL | 0.9496 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
BOC-D-FMK 634911-80-1 Apoptosis Proteases/Proteasome Caspase BOCDFMK Inhibitor inhibit BOC D FMK inhibitor