store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BMS-935177 是一种可逆的 BTK 抑制剂,IC50 值为 3 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 622 | 现货 | ||
2 mg | ¥ 913 | 现货 | ||
5 mg | ¥ 1,830 | 现货 | ||
10 mg | ¥ 2,750 | 现货 | ||
50 mg | 特惠询价 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,930 | 现货 |
产品描述 | BMS-935177 is a reversible BTK inhibitor with IC50 value of 3 nM. |
靶点活性 | BTK:3 nM |
体外活性 | In human Ramos B cells, BMS-935177 inhibits calcium flux with an IC50 of 27 nM. BMS-935177 inhibits CD69 surface expression in peripheral B cells stimulated with antiIgM and anti-IgG. Against IgG-containing immune complexdriven low affinity activating FcγRIIa and FcγRIII end points in peripheral blood mononuclear cells, BMS-935177 effectively inhibits TNFα production (IC50 = 14 nM). BMS-935177 shows mean IC50 values of 550 and 2060 nM in human and mouse whole blood, respectively[1]. |
体内活性 | BMS-935177(5, 20, and 45 mg/kg) inhibits anti-KLH antibodies of the IgG isotype at day 14, with statistically significant reductions at all doses. In satellite mice, BMS-935177 (5 mg/kg) maintains the plasma concentration above the mouse whole blood BCR-stimulated CD69 IC50 value of 2 μM for only 5 h. BMS-935177(10, 20, and 30 mg/kg) provides dose-dependently reduces both the severity and incidence of clinically evident disease in this rodent model of RA. BMS-935177(10 mg/kg) reduces the disease severity about 40%, and the percentage of animals showing any signs of disease is reduced by a third[1]. |
分子量 | 502.56 |
分子式 | C31H26N4O3 |
CAS No. | 1231889-53-4 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 117mg/mL (232.8mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.9898 mL | 9.9491 mL | 19.8981 mL | 49.7453 mL |
5 mM | 0.398 mL | 1.9898 mL | 3.9796 mL | 9.9491 mL | |
10 mM | 0.199 mL | 0.9949 mL | 1.9898 mL | 4.9745 mL | |
20 mM | 0.0995 mL | 0.4975 mL | 0.9949 mL | 2.4873 mL | |
50 mM | 0.0398 mL | 0.199 mL | 0.398 mL | 0.9949 mL | |
100 mM | 0.0199 mL | 0.0995 mL | 0.199 mL | 0.4975 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
BMS-935177 1231889-53-4 Angiogenesis Tyrosine Kinase/Adaptors BTK BMS935177 BMS 935177 Inhibitor inhibitor inhibit