Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BMS-564929 is an agonist of androgen receptor (AR, Ki of 2.11±0.16 nM).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 765 | 5日内发货 | ||
25 mg | ¥ 5,950 | 6-8周 | ||
50 mg | ¥ 7,740 | 6-8周 | ||
100 mg | ¥ 11,900 | 6-8周 |
产品描述 | BMS-564929 is an agonist of androgen receptor (AR, Ki of 2.11±0.16 nM). |
靶点活性 | Androgen receptor:(ki)2.11±0.16 nM |
体外活性 | BMS-564929 is more than 1000-fold selective for AR vs. estrogen receptors (ER) α and β, glucocorticoid receptor (GR), and mineralocorticoid receptor (MR), and approximately 400-fold selective vs. BMS-564929 shows no measurable activity in functional transactivation assays with ERα/β, GR, MR, or PR at concentrations up to 30 μM[1]. BMS-564929 exhibits a potency (EC50, calculated as the concentration at which 50% of the maximum stimulatory effect of DHT is achieved) of 0.44±0.03 nM in the C2C12 myoblast cell line. In the PEC cell line, the EC50 for BMS-564929 is 8.66±0.22 nM. progesterone receptor (PR). |
体内活性 | BMS-564929 is more than 200 times more potent in stimulation of muscle and 80 times more selective for muscle vs. prostate, compared with T propionate (TP) in the same model[1]. BMS-564929 (p.o.) shows substantially more potent activity in the levator ani, exhibiting an ED50 of 0.0009 mg/kg in the levator ani and an ED50 of 0.14 mg/kg in the prostate; a net 160-fold selectivity for muscle vs. prostate, in sexually mature, castrated male rats, a well-characterized animal model. Approximately 100% muscle stimulation is achieved at 0.1 mg/kg, reaching greater than 125% stimulation at 0.3 and 1 mg/kg. |
分子量 | 305.72 |
分子式 | C14H12ClN3O3 |
CAS No. | 627530-84-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (163.55 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.271 mL | 16.3548 mL | 32.7097 mL | 81.7742 mL |
5 mM | 0.6542 mL | 3.271 mL | 6.5419 mL | 16.3548 mL | |
10 mM | 0.3271 mL | 1.6355 mL | 3.271 mL | 8.1774 mL | |
20 mM | 0.1635 mL | 0.8177 mL | 1.6355 mL | 4.0887 mL | |
50 mM | 0.0654 mL | 0.3271 mL | 0.6542 mL | 1.6355 mL | |
100 mM | 0.0327 mL | 0.1635 mL | 0.3271 mL | 0.8177 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
BMS-564929 627530-84-1 Endocrinology/Hormones Androgen Receptor BMS564929 BMS 564929 Inhibitor inhibitor inhibit