Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BC-1215 是一种 F-box protein 3 抑制剂。它能够稳定 TRAF1-TRAF6 来抑制 Fbxo3-TRAF 激活途径。它与 ApaG 相互作用,阻碍来自人 PBMC 广谱 TH1 细胞因子的分泌。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 221 | 现货 | ||
5 mg | ¥ 497 | 现货 | ||
10 mg | ¥ 797 | 现货 | ||
25 mg | ¥ 1,330 | 现货 | ||
50 mg | ¥ 1,980 | 现货 | ||
100 mg | ¥ 2,950 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 547 | 现货 |
产品描述 | BC-1215 is an inhibitor of F-box protein 3 (FBXO3, a ubiquitin E3 ligase component, IC50=0.9 μg/mL for IL-1β release). |
靶点活性 | FBXO3:0.9 μg/mL |
体内活性 | A small molecule inhibitor BC-1215 argeting Fbxo3 was sufficient to lessen severity of cytokine-driven inflammation in several murine disease models. |
动物实验 | Tested effects of administration of BC-1215 in a model of a cecal ligation and puncture (CLP)-induced sepsis. Mice with CLP had significantly increased cytokine release compared to sham treated mice. BC-1215 treatment significantly attenuated CLP-induced secretion of all three circulating pro-inflammatory cytokines in mice . BC-1215 also decreased bacterial counts in the CLP model and modestly produced inhibition of bacterial growth using Kirby Bauer testing |
分子量 | 394.51 |
分子式 | C26H26N4 |
CAS No. | 1507370-20-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.94 mg/mL (10 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.5348 mL | 12.6739 mL | 25.3479 mL | 63.3697 mL |
5 mM | 0.507 mL | 2.5348 mL | 5.0696 mL | 12.6739 mL | |
10 mM | 0.2535 mL | 1.2674 mL | 2.5348 mL | 6.337 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
BC-1215 1507370-20-8 Others PROTAC Ligand for E3 Ligase Ligands for E3 Ligase E3 ligase-recruiting Moiety F-box protein 3 (Fbxo3) Inhibitor inhibit inflammation MLE cells BC1215 PBMC cells U937 cells TRAF BC 1215 inhibitor