Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Azumolene (EU4093 free base) 是一种 Dantrolene 的类似物,是一种肌肉松弛剂,可用于恶性高热研究。它是一种 ryanodine 受体调节剂,并通过 ryanodine 受体抑制钙释放。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 317 | 现货 | ||
2 mg | ¥ 463 | 现货 | ||
5 mg | ¥ 797 | 现货 | ||
10 mg | ¥ 1,370 | 现货 | ||
25 mg | ¥ 2,970 | 现货 | ||
50 mg | ¥ 4,550 | 现货 | ||
100 mg | ¥ 6,480 | 现货 | ||
500 mg | ¥ 12,900 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 877 | 现货 |
产品描述 | Azumolene (EU4093 free base) |
体内活性 | 1.EU4093 (azumolene sodium) is a direct acting, skeletal muscle relaxant with structural similarities to dantrolene sodium in that the para-nitro phenyl group of dantrolene sodium is replaced by a para-bromo phenyl group.?2.?The effect of EU4093 on the twitch of the intact rat soleus preparation is nearly maximal at a dose of 20 mg kg-1.?This dose of EU4093 reduces the amplitude of the twitch to 31.9% of the control value.?By comparison, dantrolene sodium reduced the twitch amplitude to 31.3% of the control value at a dose of 5 mg kg-1.?3.?The contraction of intrafusal muscle as measured by the response of spindle afferent discharge was also reduced by EU4093.?4.?The most significant difference between the effect of EU4093 and dantrolene sodium on the contraction of intrafusal muscle was that EU4093 had an appreciable depressant action at high stimulation frequencies at which dantrolene sodium had only a minimal relaxant effect on the intrafusal muscle contraction. |
别名 | 阿珠莫林, EU4093 free base |
分子量 | 349.14 |
分子式 | C13H9BrN4O3 |
CAS No. | 64748-79-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 13.89 mg/mL (39.78 mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.8642 mL | 14.3209 mL | 28.6418 mL | 71.6045 mL |
5 mM | 0.5728 mL | 2.8642 mL | 5.7284 mL | 14.3209 mL | |
10 mM | 0.2864 mL | 1.4321 mL | 2.8642 mL | 7.1605 mL | |
20 mM | 0.1432 mL | 0.716 mL | 1.4321 mL | 3.5802 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Azumolene 64748-79-4 Membrane transporter/Ion channel Metabolism Calcium Channel SOCE inhibit ryanodine EU-4093 Inhibitor Ca channels 阿珠莫林 EU 4093 relaxant EU4093 free base Ca2+ channels muscle receptor calcium EU4093 inhibitor