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Azithromycin

Azithromycin

产品编号 T6401   CAS 83905-01-5
别名: 阿奇霉素, Zithromax, CP 62993, XZ-450

Azithromycin (CP 62993) 是一种常用于细菌感染研究的大环内酯抗生素。

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Azithromycin Chemical Structure
Azithromycin, CAS 83905-01-5
规格 价格/CNY 货期 数量
50 mg ¥ 680 现货
100 mg ¥ 1,062 现货
500 mg ¥ 3,211 现货
1 mL * 10 mM (in DMSO) ¥ 748 现货
其他形式的 Azithromycin:
产品目录号及名称: Azithromycin (T6401)
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纯度: 99.9%
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天然产物信息
生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Azithromycin (CP 62993) is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections.
体外活性 Azithromycin reduces about 40% of IL-8 mRNA and protein expression in cystic fibrosis (CF) cells reaching the levels of non-CF cells. Azithromycin results in 50% and 70% reduction of NF-kappaB and AP-1 DNA binding, respectively, leading to levels of non-CF cells. Azithromycin significantly enhances the intensity of a co-stimulatory molecule, CD80, on DCs but not CD86 and CD40 in dendritic cells (DCs). Azithromycin significantly increases the production of IL-10 and Clarithromycin (CAM) significantly inhibits the production of IL-6 by DCs. Azithromycin increases IL-10 and CAM decreases IL-2 productions significantly, when naive T cells derived from spleen are co-cultured with DCs treated in advance with LPS and these macrolides.Azithromycin selectively inhibits fluid-phase endocytosis of horseradish peroxidase and lucifer yellow in J774 mouse macrophages. Azithromycin delays sequestration of receptor-bound transferrin and peroxidase-anti-peroxidase immune complexes into cell-surface endocytic pits and vesicles. Azithromycin down-regulates cell surface transferrin receptors, but not Fc gamma receptors, by causing a major delay in the accessibility of internalized transferrin receptors to the recycling route, without slowing down subsequent efflux, resulting in redistribution of the surface pool to an intracellular pool.Azithromycin inserts into the DOPC lipid bilayer, so as to decrease its cohesion and to facilitate the merging of DPPC into the DOPC fluid matrix.
细胞实验 THP-1 cells (106 cells in 1 mL RPMI medium, without antibiotics, growth factors or serum) are seeded in each well of 24-well plates and allowed to settle for 1 hour. Next, 50 μL of the test compound is added followed by 50 μL of LPS (final concentration of 10 μg/mL). After 24h (37°C and 5% CO2) the supernatants and cell pellets are collected (1200 rpm, 5 min). THP-1 cell viability is tested using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). MTT is dissolved at 2 mg/mL in PBS and aliquots are stored at -20°C. The MTT assay is performed according to the suppliers instructions. Absorbance of MTT converted into formazan is measured at a wavelength of 570 nm with background subtraction at 630 nm.
别名 阿奇霉素, Zithromax, CP 62993, XZ-450
分子量 748.98
分子式 C38H72N2O12
CAS No. 83905-01-5

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 74.9 mg/mL (100 mM)

Ethanol: 74.9 mg/mL (100 mM)

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO / Ethanol 1 mM 1.3351 mL 6.6757 mL 13.3515 mL 33.3787 mL
5 mM 0.267 mL 1.3351 mL 2.6703 mL 6.6757 mL
10 mM 0.1335 mL 0.6676 mL 1.3351 mL 3.3379 mL
20 mM 0.0668 mL 0.3338 mL 0.6676 mL 1.6689 mL
50 mM 0.0267 mL 0.1335 mL 0.267 mL 0.6676 mL
100 mM 0.0134 mL 0.0668 mL 0.1335 mL 0.3338 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Cigana C, et al. P Biochem Biophys Res Commun, 2006, 350(4), 977-982. 2. Sugiyama K, et al. Clin Exp Immunol, 2007, 147(3), 540-546. 3. Tyteca D, et al. Exp Cell Res, 2002, 281(1), 86-100. 4. Fa N, et al. Biochim Biophys Acta, 2007, 1768(7), 1830-1838. 5. Menzel M, et al. Azithromycin augments rhinovirus-induced IFNβ via cytosolic MDA5 in experimental models of asthma exacerbation. Oncotarget. 2017 Mar 18. 6. Vandooren J, et al. Differential inhibition of activity, activation and gene expression of MMP-9 in THP-1 cells by azithromycin and minocycline versus bortezomib: A comparative study. PLoS One. 2017 Apr 3;12(4):e0174853. 7. Fan Y, Li M, Ma K, et al. Dual-target MDM2/MDMX inhibitor increases the sensitization of doxorubicin and inhibits migration and invasion abilities of triple-negative breast cancer cells through activation of TAB1/TAK1/p38 MAPK pathway[J]. Cancer biology & therapy. 2019, 20(5): 617-632. 8. Xu K K, Huang Y K, Liu X, et al. Organotypic Culture of Mouse Meibomian Gland: A Novel Model to Study Meibomian Gland Dysfunction In Vitro[J]. Investigative Ophthalmology & Visual Science. 2020, 61(4): 30-30.

文献引用

1. Nicholson M W, Huang C Y, Wang J Y, et al. Cardio-and Neurotoxicity of Selected Anti-COVID-19 Drugs. Pharmaceuticals. 2022, 15(6): 765 2. Xu K K, Huang Y K, Liu X, et al. Organotypic Culture of Mouse Meibomian Gland: A Novel Model to Study Meibomian Gland Dysfunction In Vitro. Investigative Ophthalmology & Visual Science. 2020, 61(4): 30-30 3. Fan Y, Li M, Ma K, et al. Dual-target MDM2/MDMX inhibitor increases the sensitization of doxorubicin and inhibits migration and invasion abilities of triple-negative breast cancer cells through activation of TAB1/TAK1/p38 MAPK pathway. Cancer biology & therapy. 2019, 20(5): 617-632. 4. Li H, Li J, Li J, et al.Carrimycin inhibits coronavirus replication by decreasing the efficiency of programmed–1 ribosomal frameshifting through directly binding to the RNA pseudoknot of viral frameshift-stimulatory element.Acta Pharmaceutica Sinica B.2024
Diosgenin glucoside Skepinone-L Lup-20(29)-en-28-oic acid Ammonium Chloride ATG7-IN-1 Atorvastatin Thioridazine hydrochloride 16-Hydroxycleroda-3,13-dien-15,16-olide

相关化合物库

该产品包含在如下化合物库中:
微生物天然产物库 抗癌临床化合物库 抗癌药物库 抗癌上市药物库 自噬库 抗癌天然产物库 FDA上市及药典收录分子库 经典已知活性库 免疫/炎症分子化合物库 抗衰老化合物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
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% Tween 80
% ddH2O
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技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Azithromycin 83905-01-5 Autophagy Microbiology/Virology Others Antibacterial Antibiotic CP62993 inhibit 阿奇霉素 XZ 450 CP-62993 Bacterial XZ450 Zithromax CP 62993 XZ-450 Inhibitor inhibitor

 

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